What's an obscure and/or pointless thing you devote an incredible amount of mental energy to? I'll start: What would the regulatory regime look like for travel to and from Mars, where gravity and less sunlight produce rapid change in human physiology and bacterial evolution?
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The last 500 years would be different, I guess. But in broader terms life as we know it on this planet for the past 3.5 billion years probably would too.
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