The main idea of the paper is that in evolve&resequence experiments one often starts with inbred strains with known haplotypes 2/n
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We show that this information allows then one to get very precise allele frequency estimates and thus allele frequency trajectories by doing quite shallow pooled sequencing throughout the experiment 3/n
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We consider various sources of noise - such as imperfect sequencing of the founders - and assess how long can one go like this before recombination occurring throughout the experiment kills the approach 4/n
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We argue that for most realistically long experiments this approach should work well. The $$ savings are substantial and can be turned into greater experimental replication bringing much greater statistical power 5/n
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Check it out! Oh, and we would like to give a shout-out to Darren Kessner,
@tomleeturner, and@jnovembre whose HARP software made this approach possible!https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670732/ …Prikaži ovu nit
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