Game where the only enemy is you. You're going to jump off a cliff. Exit your body as your soul and talk your body into not jumping.
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Game where you play a person's heart, and have to beat in a good rhythm so that they don't hyperventilate or pass out.
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Isn't there a real life version of that where the wife has to talk you down after failing to meet a kickstarter target? :/
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it would also work other way around, your soul wants you dead and you as the player must fight yourself to survive.
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a game like you describe was submitted in the previous #LD48 contest ;) ludumdare.com/compo/ludum-da
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Sounds deep. You will slowly uncover reasons why you want to go on and live
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That sounds like a mini game for that suicidal guy in Godus :D