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Rob proslijedio/la je Tweet
I profiled two startups trying to develop blood tests to screen for cancer. They’re taking very different approaches but both teams are optimistic:https://www.cnbc.com/amp/2020/02/01/detecting-cancer-through-liquid-biopsies-freenome-grail-thrive.html …
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Adoptive transfer of T cells that express a chimeric antigen receptor against fibroblast activation protein results in a significant reduction in cardiac fibrosis and restoration of function after injury in mice.
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Through expression analysis of the gene signatures of cardiac fibroblasts obtained from healthy and diseased human hearts, we identify an endogenous target of cardiac fibroblasts-fibroblast activation protein.
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We find that cardiac fibroblasts that express a xenogeneic antigen can be effectively targeted and ablated by adoptive transfer of antigen-specific CD8+ T cells.
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CAR-T for fibrosis https://www.ncbi.nlm.nih.gov/pubmed/31511695 Jonathan Epstein
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Rob proslijedio/la je Tweet
Case Records of the
#MGH: Case 4-2020: A 52-Year-Old Woman with Seizure Disorder and Wide-Complex Tachycardia https://nej.md/2tZIXqTHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Rob proslijedio/la je Tweet
A 51-year-old Iranian man presented with severe CMV infection, which proved to be fatal over the next 29 months. Investigation determined that he had a homozygous frameshift mutation in the gene encoding a nonfunctional NOS2 protein. https://nej.md/2O5JnTg
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Rob proslijedio/la je Tweet
There's so much more to learn about
#cancer immunotherapy. Here's a new, outstanding review on checkpoint inhibitors as an adjunct to surgery@sciencemagazine https://science.sciencemag.org/content/367/6477/eaax0182 … by Suzanne Topalian, Janis Taube,@dpardol1@HopkinsMedicine@bloombergkimmel w/@ScienceVisualspic.twitter.com/45ughXTRku
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