Pavlos Msaouel, MD, PhD

@PavlosMsaouel

Assistant Professor of GU Oncology at MD Anderson Cancer Center | Tweets=my views |

Houston, TX
faculty.mdanderson.org/profiles/pavlo…
Vrijeme pridruživanja: lipanj 2017.
Rođen/a 19. siječnja
64 fotografije ili videozapisa Fotografije i videozapisi

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  1. Prikvačeni tweet
    17. kol 2018.

    Our phase II trial testing ixazomib+gemcitabine/doxorubicin in renal medullary carcinoma and other SMARCB1-negative kidney malignancies is now open . More details here:

    , , i još njih 5
    20 proslijeđenih tweetova 53 korisnika označavaju da im se sviđa
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  2. proslijedio/la je Tweet
    30. sij

    Mark your calendar: Christopher Logothetis, MD, presents "Why Cancer Control Rates Do Not Result in Proportional Survival Improvements." Weds, Feb 5, Noon-1 pm, Pickens Tower, Floor 3, Distance Learning Center (FCT3.5001)

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  3. proslijedio/la je Tweet
    prije 12 sati
    Odgovor korisnicima i sljedećem broju korisnika:

    1/2 Adjustment for covariates in the Cox model improves power and increases the likelihood of PH holding. You were caught by the "ill-defined hazard ratio without adjustment" problem. See ANCOVA chapter in

    1 proslijeđeni tweet 7 korisnika označava da im se sviđa
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  4. proslijedio/la je Tweet
    prije 12 sati

    Happy ! So many amazing women doctors everywhere.

    Today is ! At DCI Center for Prostate & Urologic Cancers, we are so thankful for our leaders, and all they do for our patients!
    1 reply 1 proslijeđeni tweet 19 korisnika označava da im se sviđa
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  5. proslijedio/la je Tweet
    prije 16 sati

    Most angiomyolipoma can be monitored without any active treatment. The 4cm cutoff for intervention is not valid. Bleeding risk is only 2%. Nephron-sparing surgery or embolization are the preferred treatment options ⁦⁩ ⁦⁦⁩

    1 reply 14 proslijeđenih tweetova 35 korisnika označava da im se sviđa
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  6. proslijedio/la je Tweet
    prije 16 sati
    Odgovor korisnicima

    Lord’s paradox is discussed here: and here . Basically, analysis of change scores is almost certainly wrong. ANCOVA is right if certain (implicit) assumptions hold.

    1 reply 2 proslijeđena tweeta 7 korisnika označava da im se sviđa
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  7. proslijedio/la je Tweet
    prije 19 sati
    Odgovor korisnicima

    This plot from Statistical Issues in Drug Development chapter 7 shows relative asymptotic variances of change score and ANCOVA compared to not using the baseline at all (just raw outcomes) as a function of the correlation between baseline and outcome.

    1 reply 6 proslijeđenih tweetova 18 korisnika označava da im se sviđa
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  8. proslijedio/la je Tweet
    prije 19 sati

    Identification of cancer driver genes based on nucleotide context (Dietlein et al.)

    26 proslijeđenih tweetova 49 korisnika označava da im se sviđa
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  9. proslijedio/la je Tweet
    2. velj

    One of the nice things about Andrew Gelman's blog is how benign posts routinely produce deep debates about foundations of statistics. This time, the concept of "calibration" (see comments): My attitude (new box in 2nd ed of my book):

    9 replies 46 proslijeđenih tweetova 274 korisnika označavaju da im se sviđa
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  10. proslijedio/la je Tweet
    2. velj
    Odgovor korisnicima

    This plot, from 's book SIDD shows how the RD and RR change as a function of the baseline risk in a compactor group, yet for all the various RD and RRs, the log odds (and thus OR) are the same.

    1 proslijeđeni tweet 16 korisnika označava da im se sviđa
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  11. proslijedio/la je Tweet
    2. velj

    Today is 02 02 2020 !!! I just had to share.

    1 proslijeđeni tweet 42 korisnika označavaju da im se sviđa
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  12. proslijedio/la je Tweet
    2. velj

    This is a major milestone of progress in cellular therapy in lymphoma! And it was initiated in the MD Anderson Lymphoma Moonshot Project. I am so glad to be a co- author.

    Cord-blood derived CD19-CAR modified NK cells induce remissions in B cell malignancies. February 6, 2020 issue of NEJM in print. Congrats to Katy Rezvani and the whole group! Stay tuned for online issue. NK cell immunotherapy works without CRS or ICANS!
    22 proslijeđena tweeta 83 korisnika označavaju da im se sviđa
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  13. proslijedio/la je Tweet
    1. velj
    Odgovor korisnicima i sljedećem broju korisnika:

    3/2: we do not observe CfB: we compute it; and in using CfB as an outcome information is lost. That information is better preserved in mRcB bc you can conditionally express the observed and expected objective of the action of interest—the ‘do(x)’.

    1 reply 1 proslijeđeni tweet 7 korisnika označava da im se sviđa
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  14. proslijedio/la je Tweet
    1. velj
    Odgovor korisnicima i sljedećem broju korisnika:

    No. Example: semiparametric models are the preferred method because of transformation invariance resulting from treating Y as ordinal. Difference in two ordinal variables is no longer ordinal in general. Think pain severity scores.

    2 proslijeđena tweeta 2 korisnika označavaju da im se sviđa
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  15. proslijedio/la je Tweet
    1. velj
    Odgovor korisnicima

    1/2: Consideration of intent and utility (psychology)may be illuminating for the issue of change-from-baseline (CfB) vs models for response conditional on baseline (mRcB). Humans intuitively construe effect as systematic change. But this intuition may make mischief for analysis.

    1 reply 7 proslijeđenih tweetova 10 korisnika označava da im se sviđa
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  16. proslijedio/la je Tweet
    1. velj
    Odgovor korisnicima i sljedećem broju korisnika:

    Unfortunately this document contains several statistical misconceptions and will perpetuate invalid responder analysis using change from baseline

    1 reply 4 proslijeđena tweeta 10 korisnika označava da im se sviđa
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  17. proslijedio/la je Tweet
    1. velj
    Odgovor korisnicima i sljedećem broju korisnika:

    Congratulations to one of the most incredible human beings! My family and I love him so much!

    1 proslijeđeni tweet 3 korisnika označavaju da im se sviđa
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  18. proslijedio/la je Tweet
    31. sij

    CAN’T. STOP. ROTATING. The human SWI/SNF complex at 3.7 A resolution, bound to a nucleosome, complements of Yanhui Xu and .

    7 proslijeđenih tweetova 56 korisnika označava da im se sviđa
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  19. proslijedio/la je Tweet
    31. sij

    Great advice thread from . I’m definitely guilty and need to improve on turnaround time.

    Mentees; if you send a paper to your PI to review/edit, ask them two questions 1. Is it ready for you to edit, inc. agreed upon final figures, a complete draft 2. Do you have time to edit it? Mentors->if above is true->don't hold onto the paper for more than 1-2 weeks!
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    2 proslijeđena tweeta 4 korisnika označavaju da im se sviđa
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  20. proslijedio/la je Tweet
    31. sij

    || Proud to share our review article 👉👉👉 as potential cancer therapeutics in myeloid malignancies - Boddu - 2019 British Journal of Haematology ⁦⁩ ⁦⁩ ⁩

    6 proslijeđenih tweetova 19 korisnika označava da im se sviđa
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  21. proslijedio/la je Tweet
    31. sij
    Odgovor korisnicima i sljedećem broju korisnika:

    Well deserved!

    1 proslijeđeni tweet 3 korisnika označavaju da im se sviđa
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