Well yes you could call that a tight constraint! The human brain does not escape the bounds of physics. We don't have advanced AIs yet but not unreasonable to expect unpredictable behaviour
I think Penrose's theory is unlikely but it doesn't matter regarding the original question, because if that is how the brain becomes aware you could build an AI with quantum microtubes to make a conscious AI. I think any feature that can evolve can be artificially replicated
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Of course. But not accidentally.
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