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POhukainen's profile
Pauli Ohukainen
Pauli Ohukainen
Pauli Ohukainen
@POhukainen

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Pauli Ohukainen

@POhukainen

Striving to even #lift, #run & #science │ #Postdoc in systems epidemiology of cardiometabolic disease at @mak_sysepi group.

Oulu, Finland
Joined May 2014

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    Pauli Ohukainen‏ @POhukainen 23 Jul 2019

    Pauli Ohukainen Retweeted Carl Brophy, MD

    Consensus on #LDL #cholesterol and #heartdisease established in early 80’s before #statins were approved. Made stronger in mid- to late 90’s with transgenic animal models. Enforced further around 2000 by trials and high-quality epi. Made iron clad in 2010’s by modern genetics.https://twitter.com/drbrophy/status/1153243537976287232 …

    Pauli Ohukainen added,

    Carl Brophy, MD @drbrophy
    One of the most thorough papers on cholesterol is the 2004 update to the ntl cholesterol guidelines. Cited >8,000 times. It incorporated the best studies done in the early 2000s and before and includes only 1 image (attached). Twitter, LDL matters! https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000133317.49796.0E … pic.twitter.com/wzTbouzpP7
    1:12 AM - 23 Jul 2019
    • 30 Retweets
    • 101 Likes
    • fly high cocainedeath Freddy Bhupinder Thakur poptartdaddy Jimmy Zulanda Gil Carvalho MD PhD Ian Cramer Respectful Living Ⓥ
    7 replies 30 retweets 101 likes
      1. New conversation
      2. Pauli Ohukainen‏ @POhukainen 23 Jul 2019

        (Yes, yes, nothing in science is iron clad but the last part refers to a point where the evidence is so overwhelming that turning it around would require unprecedented scientific breakthroughs and proof that state-of-the-art biomedical research methods are fundamentally wrong)

        1 reply 2 retweets 15 likes
        Show this thread
      3. Pauli Ohukainen‏ @POhukainen 23 Jul 2019

        All this time, competition between scientists has been fierce creating incentives for better ideas. New hypotheses have been tested and novel methodologies developed. At each incremental step, new approach could have disproven previous data but it hasn’t - quite the opposite.

        2 replies 2 retweets 17 likes
        Show this thread
      4. Pauli Ohukainen‏ @POhukainen 23 Jul 2019

        It’s like @neiltyson has said (paraphrasing), scientists never agree unless they absolutely have to. Every team thinks there’s something wrong with the rival team’s work. So when multiple groups around the world look at the same data and agree, it’s not a small thing.

        1 reply 5 retweets 20 likes
        Show this thread
      5. End of conversation
      1. New conversation
      2. JT‏ @JTMarlin77 23 Jul 2019
        Replying to @POhukainen

        What’s your LDL?

        1 reply 0 retweets 0 likes
      3. Pauli Ohukainen‏ @POhukainen 23 Jul 2019
        Replying to @JTMarlin77

        It hovers around 2mmol/l. I have pretty bad genetics

        1 reply 0 retweets 0 likes
      4. Show replies
      1. New conversation
      2. Kevin Bass, MS‏ @kevinnbass 23 Jul 2019
        Replying to @POhukainen

        but malcolm kendrick but aseem malhotra but uffe ravnskov but ivor cummins do the names of these luminaries mean NOTHING to you?

        8 replies 0 retweets 22 likes
      3. Stewie‏ @NuffinSerious 23 Jul 2019
        Replying to @kevinnbass @POhukainen

        Are PCSK inhibitors equally effective? I have some side effects to statins (like muscle twitching ) , my doctor says we should switch to PCSKs for you.

        1 reply 0 retweets 0 likes
      4. Show replies
      1. New conversation
      2. Ivor Cummins‏ @FatEmperor 23 Jul 2019
        Replying to @POhukainen

        Pull the other one Pauli - even the world's top Risk Calculators from the nerdy actuaries and other experts....spurn LDL - and rightly so. What a farce....you're embarrassing yerself 😆pic.twitter.com/vitwzCztcb

        1 reply 0 retweets 8 likes
      3. Pauli Ohukainen‏ @POhukainen 23 Jul 2019
        Replying to @FatEmperor

        They don’t evaluate lifetime risk. They’re also focused on plaque ruptures and other endpoints; not the gradual build-up of disease.

        5 replies 0 retweets 8 likes
      4. Show replies
      1. MeerkatinNZ‏ @MaureenStroud 23 Jul 2019
        Replying to @POhukainen @kevinnbass

        Minnesota Minnesota Minnesota. History is simply not on your side, Paul.

        0 replies 0 retweets 0 likes
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