Anticheats such as BattlEye have been trying to detect generic hypervisors, in particular those prevalent in the cheating community (DdiMon and hvpp), by using time-based detections. Here's some advice on that for the developers. https://vmcall.blog/battleye-hypervisor-detection/ …
One issue though - there is a trend to actually virtualize your gaming-environment, e.g Google Stadia. I have a few friends who actually play their games legitimately in a QEMU environment.