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BREAKING NEWS:
The 2019 #NobelPrize in Physiology or Medicine has been awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability.”pic.twitter.com/6m2LJclOoL
The fundamental importance of oxygen has been understood for centuries, but how cells adapt to changes in oxygen levels has long been unknown. This year’s #NobelPrize awarded work reveals the molecular mechanisms that underlie how cells adapt to variations in oxygen supply.pic.twitter.com/rsPYDH9NQ8
Oxygen sensing is central to a large number of diseases. The discoveries made by this year’s #NobelPrize laureates have fundamental importance for physiology and have paved the way for promising new strategies to fight anaemia, cancer and many other diseases.pic.twitter.com/I7oecTXHGX
2019 Medicine Laureates William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.
#NobelPrizepic.twitter.com/LiExfH74rh
When oxygen levels are low (hypoxia), HIF-1α is protected from degradation and accumulates in the nucleus, where it associates with ARNT and binds to specific DNA sequences (HRE) in hypoxia-regulated genes (1).
#NobelPrize
At normal oxygen levels, HIF-1α is rapidly degraded by the proteasome (2). Oxygen regulates the degradation process by the addition of hydroxyl groups (OH) to HIF-1α (3).
#NobelPrize
The VHL protein can then recognise and form a complex with HIF-1α leading to its degradation in an oxygen-dependent manner (4).
#NobelPrize
Learn more about the 2019 #NobelPrize in Physiology or Medicine
Press release: https://www.nobelprize.org/prizes/medicine/2019/press-release/?utm_source=Twitter&utm_medium=Social&utm_campaign=twitter_tweet …
Advanced information: https://www.nobelprize.org/prizes/medicine/2019/advanced-information/?utm_source=twitter&utm_medium=Social&utm_campaign=twitter_tweet …pic.twitter.com/2nUowdzCKS
Congratulations William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza! https://www.sciencedirect.com/science/article/pii/S109727650800292X … http://dipbsf.uninsubria.it/monti/BFPN%202010/Biblio%20BFPN%202010/BFPN%20HIF1/HIF%20Semenza%202003.pdf … #cancer #biochemistry #scicomm @Harvard @HopkinsMedicine @UniofOxfordpic.twitter.com/JxDD14DdNQ
So the @NobelPrize in physiology and medicine went to 3 white dudes. No surprise there. I challenge you to tell me that no key experiments for this discoveries where performed my female scientist
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