@razibkhan Sorry, meant to say, what can you do WITH it.
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Freudian slip there....
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Yes, what can Razib do about polygenic scores? :D
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My understanding is it's y-hat from a regression model, where Y is some aspect of phenotype (eg, education) and the X vector is a bunch of genetic SNPs. It provides a lower bound estimate of heritability vs tein studies. Is that right?
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This is what the leading expert says https://www.edge.org/response-detail/27099 …pic.twitter.com/WlkI8Z6Mq9
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Probably the best thing you could do with it would be to destroy it, long before your health or life insurance provider ask to see it.
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For an example of the utility of a medical PRS see my tweet and the paper in Matt’s response. Won’t always be a potent and semi-universal treatment for a multicausal risk. But sometimes there is. https://twitter.com/clarksterh/status/1031360503065526272 …
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