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Prikvačeni tweet
Interested in how populations adapt to a new niche to which they have gained access following the acquisition of a novel trait? Our preprint addresses this question. Here is a short thread on some of our findings 1/
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Motor proteins have always fascinated me. I have showed students videos of dynein and kinesin transporting goods each of the times I’ve TA’d. A beautiful example of the universe within.https://twitter.com/hinczewskilab/status/1224186166888497152 …
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It appears that #45 will walk acquitted of all charges come Wednesday. Such an acquittal is a prime example of what privilege looks like. Come Wednesday, #45 will forever be, in my book, considered America’s Type II Error.
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On two separate occasions this week I was told to start thinking about the classes and content I would like to teach as faculty. Now, I’m usually not one for heebie jeebies, but I think the universe is talking to me.
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Nkrumah Grant proslijedio/la je Tweet
the effect of R on my inner statisticianpic.twitter.com/JHhYhYtIxp
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Nkrumah Grant proslijedio/la je Tweet
Collaborative post-doc position open!https://thewoodslab.wordpress.com/2020/01/28/collaborative-post-doc-position-open/ …
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Nkrumah Grant proslijedio/la je Tweet
What happens after an evolutionary innovation? Very interesting study by
@TanushJagdish@RELenski@NkrumahGrant (and others) that describes this in great detail.https://www.biorxiv.org/content/10.1101/2020.01.22.915975v1 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Nkrumah Grant proslijedio/la je Tweet
I'm thrilled to announce that I have accepted a postdoc position with Jake Scott (
@CancerConnector) at the Cleveland Clinic Lerner Research Institute@CCLRI! I'll be studying the evolution of resistance in both bacteria and cancer. I can't wait to get started!Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
See the full results here!https://www.biorxiv.org/content/10.1101/2020.01.22.915975v1 …
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Our results suggest that genomes exhibit a latent potential for adaptation to new niches. However, the persistent high rates of cell death suggest that long periods of adaptation may sometimes be necessary before a new ecotype becomes fully fitted to its new position in nature.
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We also found parallel amplifications in six of the genomes. Among the amplifications, maeA, was always included. Competition assays revealed that this gene was highly beneficial, conferring a fitness advantage upwards of 25%. 9/pic.twitter.com/a4n9rQVBfn
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Interestingly, death was still observed in the Cit+ clone some 20,000 generations after the phenotype evolved. Damned if you do, damned if you don’t. 8/
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We also discovered that the evolution of aerobic growth on citrate is associated with elevated cell mortality; Cell death evolved!!! We observed high proportions of death on the order of 29-53% depending on clone and medium treatment. 7/pic.twitter.com/F6L4OHwY2k
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The growth rates of most DM0 and DM25 evolved clones increased and their lag-phase shortened during the experiment. 6/pic.twitter.com/HfvhLWzI8k
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The populations that evolved in the citrate-only DM0 medium accumulated more mutations than those in DM25. Their mutation spectra were different, too. Genome evolution in DM0 was dominated by IS insertions. 5/pic.twitter.com/2PmJAIFHDI
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We also evolved these 12 populations in citrate media containing glucose (DM25 – the basal LTEE media). We compared the growth of the citrate-only evolved clones to the growth of their ancestors in both DM0 and DM25. 4/
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To address this question, we isolated three early Cit+ clones and spontaneous Ara+ mutants of each. We then evolved two replicate populations of each clone and revertant, generating 12 total populations that were then evolved for 2500 generations in citrate only media (DM0). 3/
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We were interested in how the sole population that evolved the ability utilize citrate in th LTEE (herein referred to as Cit+) would adapt to the newly accessible citrate-only environment. 2/
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Nkrumah Grant proslijedio/la je Tweet
So excited!!!!!!!!! The tutorial I built for NumPy has been published!!

If you're a beginner and you want to learn the basics of #NumPy, take a look!! https://numpy.org/devdocs/user/absolute_beginners.html …@numpy_team#SeasonOfDocs#TechnicalWriting#OpenSource#DataScience#MachineLearningHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Nkrumah Grant proslijedio/la je Tweet
Eagerly accepting applicants to join me on this grant from diverse populations (defined in link). Please consider contacting me if you meet the
@NIH criteria (or even if you don’t!). https://grants.nih.gov/grants/guide/pa-files/PA-18-906.html …#strengthindiversityPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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