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Prikvačeni tweet
Very pleased to share that my PhD work has finally found a resting place. It can be accessed here:https://www.pnas.org/content/early/2020/01/17/1905730117 …
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NEW
#LMBpublications Pressure sensing through Piezo channels controls whether cells migrate with blebs or pseudopods.https://ift.tt/37vTTv7Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Would be amazing to a cell mechanics course through this EMBO program.https://twitter.com/India_Alliance/status/1206838375002583040 …
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Big thanks to my PhD supervisors Alexandre Kabla
@Cambridge_Uni and Rob Kay@MRC_LMB and all the Kay lab members for all the help and support during this work.@stjohnscam for the doctoral funding to pursue my Phd at Cambridge.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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Interesting for
#calciumsignaling +#CellMigration +#mechanosignaling@Nishit24 et al@biorxivpreprint shows that in#Dicty during chemotaxis almighty#Piezo1 channel allows Ca2+ influx & further activation of myosinII [http://bit.ly/2D10dMV ]#mechanobiology#preprint#Sciencepic.twitter.com/6nalRsHABnHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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We believe that cells which have smaller nuclei (like Dictys) will have a mechanosensitive module driven by mechanosensitive ion channel on plasma membrane.
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Piezo null mutants chemotaxed very poorly under mechanically resistive environment. Blebbing is necessary to chemotax under such conditions as has been shown earlier by Kay lab.
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But, amongst all the mechanosensitive ion channel mutants, Piezo null mutants did not show protrusion switching under compressive loading.Pzo null mutants are expressing LifeAct-GFP while WT cells express LifeAct-RFP. WT cells formed blebs when load was applied but not mutants.pic.twitter.com/I7AqQby4xb
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Squashing the cells also lead to cortical enrichment of myosin on similar timescales. Here cells expressing GFP-mhcA can be seen under dynamic loading.pic.twitter.com/UEOIQgKMsV
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Protrusion switching occured at a very fast timescale(~20sec). In this movie, Dictys are expressing a marker for F-actin and a uniaxial load is applied from top using a cell squasher system.pic.twitter.com/fyzSjO9FSQ
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We showed that applying loads as little as 100Pa can shift the migratory mode of Dictys from pseudopodia to blebspic.twitter.com/4OycZiIKpR
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Dictys are simply amazing. If I were to teach biology from scratch to myself, I'd start with Dicty.https://twitter.com/Roy_Lab_Thinks/status/1218925657196941313 …
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MINFLUX, a new super-resolution microscopy technique - by HFSP Young Investigator Grant holder Jonas Ries
@embl and HFSP Program Grant holder Stefan Hell@mpi_mr_hd and colleagues#superresolutionmicroscopy http://bit.ly/35Zh5QB pic.twitter.com/By24sEf3su
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Love pictures of the endoplasmic reticulum and their interactions with other organelles. The imaging methods developed in the past decade or so really show the dynamic ER membranes in all their glory.https://twitter.com/Po_Strale/status/1218067894820659200 …
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This really is a great opportunity for undergrads to come spend a summer in Lausanne and do some fun research! Ask
@salazarafra or@GatjensDiego who were in our lab the last two summers. One week left to apply!https://twitter.com/YSchaerli/status/1217722241347092482 …
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It is to no surprise that academic research has evolved from one of the most fulfilling careers to more stressful one especially for ECRs. Adding to this is the non-permanency of the role and fact that most people immigrate to places far away from loved ones and families.https://twitter.com/wellcometrust/status/1217418681749295106 …
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Global regulation of the ER network by lysosomes described in
While we must protect this pride in research careers, our