Nicky Scheefhals

@NickyScheefhals

PhD Candidate, Neurobiology, Super-Resolution Microscopy, Utrecht University, MacGillavry lab

Utrecht, Nederland
Vrijeme pridruživanja: prosinac 2017.

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  1. Prikvačeni tweet
    8. lis 2019.

    Our paper is out!!🎉 Shank proteins anchor the endocytic zone to the postsynaptic density to govern efficient trafficking and signaling of mGluR5 at synapses to modulate neuronal functioning. Full article:

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  2. proslijedio/la je Tweet
    13. pro 2019.

    "Okay, pipettes down everyone, it's Christmas picture time". 🎅🎄

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  3. proslijedio/la je Tweet
    2. pro 2019.

    So much creativity in the lab! Pick your favorite poem (or subsynaptic structure...)

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  4. proslijedio/la je Tweet
    6. stu 2019.

    The November issue is online: —> The cover shows a lab-specific rendition of Rembrandt highlighting work by Anna Akhmanov and co-workers describing that Gas2L1 stimulates branching and reduces axon outgrowth. —>

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  5. proslijedio/la je Tweet
    15. lis 2019.

    Yay 🥳! These ER nanostructures in neurons are shining in today's issue of (thanks to )! More on neuronal ER and its role in presynaptic function in the full article 👉

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  6. proslijedio/la je Tweet
    11. lis 2019.

    Shank proteins control mGluR5 trafficking and signaling

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  7. 8. lis 2019.
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  8. 8. lis 2019.

    6/ Very excited to share our work!! And many thanks to all who contributed Margriet Westerveld & Casper Hoogenraad

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  9. 8. lis 2019.

    5/ Based on these findings, we present a model in which coupling of the EZ to the PSD by Shank proteins enables local recycling of mGluRs, allowing the synapse to balance the density of mGluRs at the membrane to efficiently modulate neuronal functioning.

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  10. 8. lis 2019.

    4/ The ASD-associated T1127M mutation in SHANK2 disrupts these processes, underlining the relevance of understanding the functional relationship between Shank proteins and mGluR signaling in the context of human neurodevelopmental disorders.

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  11. 8. lis 2019.

    3/ The PSD-EZ coupling maintained by Shank proteins balances synaptic mGluR5 levels and modulates mGluR5-mediated calcium responses and ERK1/2 activation.

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  12. 8. lis 2019.

    2/ We report that Shank proteins do not directly anchor mGluR5 at the synapse but link essential components of the endocytic zone (EZ) to the postsynaptic density (PSD).

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  13. 8. lis 2019.

    1/ We show that Shank proteins regulate activity-induced internalization of mGluR5 in spines.

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  14. 7. lis 2019.
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  15. proslijedio/la je Tweet
    3. lis 2019.

    Worden je hersenen steeds slimmer? Nathan zocht het uit bij waar hij - nog levende! - hersencellen van muizen onder een microscoop te zien kreeg. Hele video: . Zelf ontdekken? Dat kan op 6 oktober!

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  16. proslijedio/la je Tweet
    3. lis 2019.

    Truly thrilled to drop this thread for you all about our paper out today in The 🔥 thread starts here 1/

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  17. proslijedio/la je Tweet
    30. ruj 2019.

    | presents two combined hot topics, super resolution imaging and CRISPR/Cas9, into one study. Arthur de Jong, , Join the parallel session on Mon 7 oct, 15.00 am

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  18. proslijedio/la je Tweet
    26. ruj 2019.

    Want to try ORANGE? Our knock-in constructs to tag endogenous proteins in neurons with CRISPR/Cas9-mediated genome editing are now available on AddGene: Tag your favorite cytoskeletal proteins, signaling molecules, synaptic scaffolds, channels, receptors!

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  19. 2. ruj 2019.

    Also, visit poster #17 on dissecting the endocytic zone!

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  20. 2. ruj 2019.

    Very excited to attend and present my data at the European Synapse Meeting 2019! Interested in the dynamic organization of glutamate receptors resolved with super-resolution microscopy, come visit my talk on Tuesday in session 3 - “Synaptic Function & Transmission”!

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