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Prikvačeni tweet
Our paper is out!!
Shank proteins anchor the endocytic zone to the postsynaptic density to govern efficient trafficking and signaling of mGluR5 at synapses to modulate neuronal functioning. Full article: https://doi.org/10.1016/j.celrep.2019.08.102 … @CellReports@hdmacgillavry@LisaCatsburgpic.twitter.com/XPyCivMydF
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Nicky Scheefhals proslijedio/la je Tweet
"Okay, pipettes down everyone, it's Christmas picture time".

#bestlabmates@LisaCatsburg@NickyScheefhals@yujie231@FreAmeLie@XingxiuPanpic.twitter.com/swf55dIa00
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Nicky Scheefhals proslijedio/la je Tweet
So much creativity in the lab! Pick your favorite poem (or subsynaptic structure...)pic.twitter.com/Iik0CoxGzi
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Nicky Scheefhals proslijedio/la je Tweet
The November issue is online: —> https://www.embopress.org/toc/14693178/2019/20/11 … The cover shows a lab-specific rendition of Rembrandt highlighting work by Anna Akhmanov
@UniUtrecht and co-workers describing that Gas2L1 stimulates#axon branching and reduces axon outgrowth. —> https://www.embopress.org/doi/abs/10.15252/embr.201947732 …pic.twitter.com/22JlR4NBwd
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Nicky Scheefhals proslijedio/la je Tweet
Yay
! These ER nanostructures in neurons are shining #onthecover in today's issue of@embojournal (thanks to@katpyxa)! More on neuronal ER and its role in presynaptic function in the full article
https://www.embopress.org/doi/abs/10.15252/embj.2018101345 …https://twitter.com/embojournal/status/1184066669402087424 …
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Nicky Scheefhals proslijedio/la je Tweet
Shank proteins control mGluR5 trafficking and signalinghttp://bit.ly/2MwH7mJ
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Very happy this story is out there! For the english version, visit: https://uu.nl/en/news/collaboration-between-crucial-proteins-in-signal-transmission-clarified … https://twitter.com/UUBeta/status/1181588349573828608 …pic.twitter.com/O1lcJQD4Ax
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6/ Very excited to share our work!! And many thanks to all who contributed
@LisaCatsburg@hdmacgillavry@BlanpiedT Margriet Westerveld & Casper HoogenraadPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
5/ Based on these findings, we present a model in which coupling of the EZ to the PSD by Shank proteins enables local recycling of mGluRs, allowing the synapse to balance the density of mGluRs at the membrane to efficiently modulate neuronal functioning.
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4/ The ASD-associated T1127M mutation in SHANK2 disrupts these processes, underlining the relevance of understanding the functional relationship between Shank proteins and mGluR signaling in the context of human neurodevelopmental disorders.
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3/ The PSD-EZ coupling maintained by Shank proteins balances synaptic mGluR5 levels and modulates mGluR5-mediated calcium responses and ERK1/2 activation.
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2/ We report that Shank proteins do not directly anchor mGluR5 at the synapse but link essential components of the endocytic zone (EZ) to the postsynaptic density (PSD).
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1/ We show that Shank proteins regulate activity-induced internalization of mGluR5 in spines.
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Nicky Scheefhals proslijedio/la je Tweet
Worden je hersenen steeds slimmer? Nathan zocht het uit bij
@UniUtrecht waar hij - nog levende! - hersencellen van muizen onder een microscoop te zien kreeg. Hele video: http://bit.ly/NathanUniversiteitUtrecht …. Zelf ontdekken? Dat kan op 6 oktober!#WVDW19#ontdekhetlekkerzelfpic.twitter.com/L5dXT6ocZpHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Nicky Scheefhals proslijedio/la je Tweet
Truly thrilled to drop this thread for you all about our paper out today in
@CellCellPress https://authors.elsevier.com/c/1ZqpiL7PXYWWO The
thread starts here 1/Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Nicky Scheefhals proslijedio/la je Tweet
#physics#lifesciences |@Jelmerwillems presents two combined hot topics, super resolution imaging and CRISPR/Cas9, into one study.@UniUtrecht Arthur de Jong,@NickyScheefhals,@hdmacgillavry Join the parallel session on Mon 7 oct, 15.00 am#DBP19#NeuronsandSensingpic.twitter.com/Fowojvq4qO
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Nicky Scheefhals proslijedio/la je Tweet
Want to try ORANGE? Our knock-in constructs to tag endogenous proteins in neurons with CRISPR/Cas9-mediated genome editing are now available on AddGene: https://www.addgene.org/Harold_MacGillavry/ … Tag your favorite cytoskeletal proteins, signaling molecules, synaptic scaffolds, channels, receptors!pic.twitter.com/ptrSUfG4uR
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Also, visit poster #17
@LisaCatsburg on dissecting the endocytic zone!Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Very excited to attend and present my data at the European Synapse Meeting 2019! Interested in the dynamic organization of glutamate receptors resolved with super-resolution microscopy, come visit my talk on Tuesday in session 3 - “Synaptic Function & Transmission”!pic.twitter.com/jeO6ss78Gi
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