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NickSzabo4's profile
Nick Szabo 🔑
Nick Szabo 🔑
Nick Szabo  🔑
@NickSzabo4

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Nick Szabo  🔑

@NickSzabo4

Blockchain, cryptocurrency, and smart contracts pioneer. (RT/Fav/Follow does not imply endorsement). Blog: http://unenumerated.blogspot.com 

Joined June 2014

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    1. zooko‏ @zooko 14 Jul 2014
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      Replying to @zooko

      @NickSzabo4 … But the generic advice "eat no carbs!" is not obviously wrong.

      1 reply 0 retweets 0 likes
    2. Nick Szabo  🔑‏ @NickSzabo4 14 Jul 2014
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      Replying to @zooko

      @zooko Ppl w/low-carb ancstrs ~ maladapted to carbs, low-milk ancstrs ~ maladapted to milk. Ppl w/low-cholesterol ancstrs? #MuchYetToLearn

      2 replies 0 retweets 1 like
    3. zooko‏ @zooko 15 Jul 2014
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      Replying to @NickSzabo4

      @NickSzabo4 I'm arguing that *even* descendants of early farmers improve health by cutting carbs. Perhaps others improve even more.

      1 reply 0 retweets 1 like
    4. Nick Szabo  🔑‏ @NickSzabo4 15 Jul 2014
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      Replying to @zooko

      @zooko Where's you're evidence for that claim? (Studies that include non-early-farmer descendants obviously aren't good evidence for it).

      2 replies 0 retweets 1 like
    5. zooko‏ @zooko 15 Jul 2014
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      Replying to @NickSzabo4

      @NickSzabo4 I will provide some evidence. But first, I'd like to argue that the burden of proof should be in the other direction. …

      1 reply 0 retweets 0 likes
    6. zooko‏ @zooko 15 Jul 2014
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      Replying to @zooko

      @NickSzabo4 … Even absent some specific measurements or experiments on some modern strains of human, I think the default assumption …

      2 replies 0 retweets 0 likes
    7. Nick Szabo  🔑‏ @NickSzabo4 15 Jul 2014
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      Replying to @zooko

      @zooko No, it's a terrible assumption. Even simplest carb digestion genetic difference gives factor of 8 different risk of obesity.

      2 replies 0 retweets 0 likes
    8. zooko‏ @zooko 15 Jul 2014
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      Replying to @NickSzabo4

      @NickSzabo4 Right, and I'm saying that's *not* evidence that carb consumption is harmless, or even helpful, to some people.

      1 reply 0 retweets 0 likes
    9. zooko‏ @zooko 15 Jul 2014
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      Replying to @zooko

      @NickSzabo4 That's evidence that carb consumption is 8 times as harmful to some other people.

      2 replies 0 retweets 0 likes
    10. Dirk Loss‏ @dloss 15 Jul 2014
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      Replying to @zooko

      @zooko @NickSzabo4 Is there an easy way to test if carbs are particularly harmful for a given person?

      2 replies 0 retweets 0 likes
      Nick Szabo  🔑‏ @NickSzabo4 15 Jul 2014
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      Replying to @dloss

      @dloss @zooko Sequence your genome and deduce salivary amylase count gives best info. Next best, relative # ancestors in hi-carb ag.

      1:21 PM - 15 Jul 2014
      1 reply 0 retweets 0 likes
        1. New conversation
        1. Nick Szabo  🔑‏ @NickSzabo4 15 Jul 2014
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          Replying to @NickSzabo4

          @dloss @zooko There are also direct tests for amylase in saliva -- don't know if they are practical for this purpose though.

          2 replies 0 retweets 0 likes
        2. zooko‏ @zooko 15 Jul 2014
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          Replying to @NickSzabo4

          @NickSzabo4 I don't see evidence that having a high count of AMY1 copies means that it is safe for you to eat carbs. @dloss

          2 replies 0 retweets 0 likes
        3. Nick Szabo  🔑‏ @NickSzabo4 15 Jul 2014
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          Replying to @zooko

          @zooko Cheap alt diet (dairy & satfat) ) prob hrmfl to some pops & you will be 8 * effective if focus your msg on highest 10% carb risk.

          1 reply 0 retweets 0 likes
        4. zooko‏ @zooko 15 Jul 2014
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          Replying to @NickSzabo4

          @NickSzabo4 http://www.nature.com/ng/journal/v46/n5/abs/ng.2939.html … is consistent with the hypothesis that AMY1 is *partially protective* against carbs. …

          1 reply 0 retweets 1 like
        5. zooko‏ @zooko 15 Jul 2014
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          Replying to @zooko

          @NickSzabo4 Analogy: alcoholism has high heritability. There must be some gene(s) which predispose one to alcoholism. …

          1 reply 0 retweets 0 likes
        6. zooko‏ @zooko 15 Jul 2014
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          Replying to @zooko

          @NickSzabo4 … If we identify a gene which makes you 8X vulnerable to alcoholism, then it would be a mistake to say …

          1 reply 0 retweets 0 likes
        7. zooko‏ @zooko 15 Jul 2014
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          Replying to @zooko

          @NickSzabo4 "People who don't have this gene: drink more alcohol, for your health!" That advice would be exceeding the evidence.

          2 replies 0 retweets 1 like
        8. Nick Szabo  🔑‏ @NickSzabo4 15 Jul 2014
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          Replying to @zooko

          @zooko But it would be good reason to recommend red wine (assuming its alleged health benefits) selectively, rather than universally.

          0 replies 0 retweets 1 like
          9. End of conversation

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