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Prikvačeni tweet
Our February 2020 issue is live: https://go.nature.com/2TLapD5 Topics include molecular properties of promoters and enhancers; genetics of human ageing; cis-acting long non-coding RNAs; and the interplay between mobile genetic elements and host defence systemspic.twitter.com/xeh5OUS9HO
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Currently
#free to access until 15 March 2020:https://twitter.com/NatureRevGenet/status/1207247839434330112 …
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Nature Reviews Genetics proslijedio/la je Tweet
#Free for 1 month: Towards a comprehensive catalogue of validated and target-linked human enhancers https://go.nature.com/2O6ezSC#Review by@MollyGasp, Jacob Tome &@JShendurepic.twitter.com/UrHlGDaOJe
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Nature Reviews Genetics proslijedio/la je Tweet
a great review for both beginners and experienced researchers in the field of
#enhancers@MollyGasp@JShendure@NatureRevGenethttps://www.nature.com/articles/s41576-019-0209-0?draft=collection …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Nature Reviews Genetics proslijedio/la je Tweet
The working culture of scientific research can be toxic. This perspective explores what the problems are, and what some of the solutions may be.
@NatureChemistry#WorkLifeBalance#DiversityinSTEMhttps://www.nature.com/articles/s41557-019-0410-y …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Features used to distinguish promoters and enhancers https://go.nature.com/2GBiYcc
#Figure from our recent Review "Determinants of enhancer and promoter activities of regulatory elements", featured on our February coverpic.twitter.com/mepdoQFbZD
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Nature Reviews Genetics proslijedio/la je Tweet
Editorial: As the United Kingdom leaves the EU, the future of a research relationship must be built on continued collaboration and compromise.https://go.nature.com/2S1NIrN
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Original articles: Lee, J.-S. & Mendell, J. T. Mol. Cell https://doi.org/10.1016/j.molcel.2019.12.011 … (2020) Lai, F. et al. Mol. Cell https://doi.org/10.1016/j.molcel.2019.12.029 … (2020)
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Two new studies in
@MolecularCell report a role for antisense oligonucleotides in inducing transcriptional termination, with important implications for the interpretation of functional studies of long non-coding RNAs.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
A means to an end for transcription? https://go.nature.com/2t4eCH8
#ResearchHighlightpic.twitter.com/wDMGFGxbb7
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Nature Reviews Genetics proslijedio/la je Tweet
Even though there may be a million+ enhancers in the human genome, understanding their role is formidable. And so is this review, by
@MollyGasp Jacob Tome and@JShendure@NatureRevGenet https://www.nature.com/articles/s41576-019-0209-0 … A great summary figurepic.twitter.com/nubQD7GPww
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Original article: Blake, L. E. et al. A comparison of gene expression and DNA methylation patterns across tissues and species. Genome Res. https://doi.org/10.1101/gr.254904.119 … (2020)
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A study in
@genomeresearch reports gene expression and DNA methylation profiles of multiple tissues sampled from the same individuals across humans, chimpanzees and rhesus macaques.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
COMPARATIVE GENOMICS: A primate view of gene expression https://go.nature.com/2RXzMPz
#ResearchHighlight by@LinkoNRGpic.twitter.com/B3jAjOj6Vm
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Post, Y. et al. Snake venom gland organoids. Cell 180, 233–247 (2020)https://www.sciencedirect.com/science/article/pii/S0092867419313236 …
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Original articles: Suryamohan, K. et al. The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins. Nat. Genet. 52, 106–117 (2020) https://go.nature.com/2RBBnvM
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Two new studies on snake venom glands have implications for improved anti-venom development. One describes the de novo assembly of an Indian cobra reference genome and venom gland transcriptome; the other describes the derivation of snake venom gland organoids.
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GENOMICS: Omics and organoids — a route to improved anti-venom https://go.nature.com/2RBBnvM
#ResearchHighlightpic.twitter.com/wNqBpMjjqT
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Nature Reviews Genetics proslijedio/la je Tweet
We wrote the review that I wished I'd had when I started my PhD in gene regulation & genomics! Read for our take on the past 40 yrs of enhancer biology, a def of an "enhancer", and how we think modern tech (like CRISPR screens) will enable the next era of understanding the genomehttps://twitter.com/NatureRevGenet/status/1222103381306675200 …
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While this Review focuses on enhancers, in particular mammalian enhancers, many of the assays and concepts described are potentially applicable to other classes of non-coding DNA regulatory elements.
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If the evidence falls short of this threshold, as it currently does for nearly all candidate enhancers, the authors suggest strong, moderate and weak tiers to describe candidate enhancers with less or conflicting evidence.
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