"Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus." -> read now: go.nature.com/3d9UhlQ #covid19
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Nature Medicine is a research journal devoted to publishing the latest advances in translational and clinical research for scientists and physicians.
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Children infected with the #COVID19 outbreak coronavirus, SARS-CoV-2, show mild symptoms but prolonged shedding of viral RNA in feces, suggesting that the fecal–oral route might play a role in virus transmission #CORONAVIRUS
go.nature.com/2QdUY3Y
New results indicate that surgical face masks could prevent transmission of human #coronavirus (and #flu) from symptomatic individuals - Read now: go.nature.com/2UCvbVM #COVID19
A longitudinal analysis of humoral immune responses in patients with #COVID19 with varying disease severity reveals that mortality does not correlate with antiviral antibody levels but, instead, with slower seroconversion.
nature.com/articles/s4159 #immunology
AI technology has made new progress in detecting different types of brain trauma: nature.com/articles/d4159
Humanitarian aid must be allowed to enter the besieged Tigray region of Ethiopia.
Correspondence from Wasan M. Kumar, Bereket A. Gebregziabher, Reiye E. Mengesha and Paul Wise
nature.com/articles/s4159
Disruption of the #circadianclock has been linked to #cancer and alterations in cancer #metabolism and this has implications for therapeutic development: go.nature.com/2roORgt
Researchers at have designed an #ArtificialIntelligence -powered microscope able to detect tumor cells in histology slides that could accelerate #pathology workflows for #cancer diagnosis―Read full paper 👉 rdcu.be/bOzGe #digitalmedicine #Biotechnology #AI
A single-cell analysis of tumor-infiltrating T cells from 16 cancer types identifies new T cell subsets and a stress response cell state enriched in tumors resistant to immunotherapy.
nature.com/articles/s4159
To celebrate #BlackHistoryMonth , we're highlighting pieces by and about fantastic Black researchers in the United States. First up: , the founder of , shares ways you can better support Black trainees in the biomedical sciences
The muscle-secreted, exercise-induced peptide hormone apelin decreases with #aging and sarcopenia, and its repletion in aged mice with recombinant protein improves muscle mass and function: go.nature.com/2NZrpzz
Nature Medicine summarizes all the research you need to know this week on the #COVID19 pandemic. This week, read about the convalescent plasma transfusion study showing promise for treating critically ill patients with #coronavirus disease 2019 go.nature.com/2xKUTyp
Despite elevated brain #amyloid pathology, a unique human case harboring a rare mutation in #APOE is reported by and colleagues to be resistant to inherited #Alzheimer’s disease | go.nature.com/2pHhlVf
Initial results from a first-in-human study show that PET imaging with PD-L1 antibodies outperforms immunohistochemistry- or RNA-sequencing-based biomarkers for prediction of clinical response to #immunotherapy: go.nature.com/2DNW412
Researchers at report an #AI framework able to predict malignancy risk of lung nodules on CT scans that might improve early lung #cancer detection | go.nature.com/2LSMaAz| #ArtificialIntelligence #deeplearning
Humanitarian aid must be allowed to enter the besieged Tigray region of Ethiopia.
Correspondence from Wasan M. Kumar, Bereket A. Gebregziabher, Reiye E. Mengesha and Paul Wise
nature.com/articles/s4159
Breadth of concomitant immune responses prior to patient recovery: a case report of a non-severe #COVID19 #COVIDー19 #COVID19Aus
The race for coronavirus vaccines: a graphical guide nature.com/articles/d4158
Nature Medicine summarizes all the research you need to know this week to keep on top of how science is responding to the #COVID19 pandemic. go.nature.com/2xva91Y #coronavirus
A single-cell analysis of tumor-infiltrating T cells from 16 cancer types identifies new T cell subsets and a stress response cell state enriched in tumors resistant to immunotherapy.
nature.com/articles/s4159
Humanitarian aid must be allowed to enter the besieged Tigray region of Ethiopia.
Correspondence from Wasan M. Kumar, Bereket A. Gebregziabher, Reiye E. Mengesha and Paul Wise
nature.com/articles/s4159
Injection of a light-activated #genetherapy vector combined with the wearing of light-stimulating goggles achieves partial vision restoration in a blind patient with retinitis pigmentosa.
nature.com/articles/s4159 #optogenetics #RareDisease
11 trailblazing early-career researchers, shaping the future of #medicine, share what they are most excited about right now and where their research is going in the next 5 years - read now: go.nature.com/3C8xLYS
A full night of sleep deprivation causes attenuated & delayed neuronal responses that correlate w/impaired cognition go.nature.com/2yB77cm
Results from a phase 3 randomized clinical trial demonstrate that MDMA-assisted therapy is safe and effective for treating patients with severe post-traumatic stress disorder.
nature.com/articles/s4159 #PTSD
Single-cell #transcriptomics and #proteomics profiling of #COVID19 samples reveals immune and HSPC changes that are differentially associated with disease severity go.nature.com/3dz5qiE
First clinical use of engineered bacteriophages for the treatment of disseminated mycobacterial infection | go.nature.com/2GOvwwe
For #InternationalWomensDay- we have a correspondence discussing women's rights in Iran in the face of oppression
In recovered #COVID19 patients, virus spike-specific #antibodies were consistently elicited, but neutralizing activity was variable and inversely correlated with the proportion of CCR6+CXCR3- spike-specific circulating T follicular helper cells.
SARS-CoV-2 is not unique in its ability to cause long-term sequelae.
In our latest Review: Akiko Iwasaki, Jan Choutka & colleagues discuss what we know (& don't know) about unexplained post-acute infection syndromes
Advancements in MRI are giving us an unprecedented look at the fetal brain. Read more in our feature story: go.nature.com/2m2oFnz
A cross-sectional study of hospitalized patients with #COVID19 and a longitudinal follow-up study of patients with #COVID_19 suggest that #SARS_COV_2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset. #AntibodyTesting #Antibody.
Flaws in ivermectin data suggest that COVID-19 meta-analyses need rethinking
Correspondence from Jack Lawrence and colleagues
nature.com/articles/s4159
Scientists have succeeded in fixing a DNA error responsible for #cysticfibrosis in a mouse model of the disease:
Organ-specific #aging clocks for multiple #brain and body systems show that the #biologicalage of one organ system selectively influences the aging of multiple other systems via specific aging pathways
Researchers and colleagues @sloan_kettering report a deep learning framework for real-world digital pathology data that achieves clinical performance for #cancer diagnosis | go.nature.com/2JAkxcE #artificialintelligence
A new study estimates that the overall symptomatic case fatality risk - the probability of dying after developing symptoms of #COVID19 in Wuhan - was about 1.4%. Read now at go.nature.com/3a7sFMs #SARSCoV2
A high-throughput platform to find rare #Tcells that recognize shared cancer #neoantigens identifies TCRs specific for a conserved and therapeutically actionable epitope in mutant PIK3CA, a common driver oncogene
First-generation students, whose parents do not have degrees, are under-represented on MD-PhD programmes and need better support, argue and colleagues at #firstgen nature.com/articles/s4159
Rotten eggs get their awful stink from hydrogen sulfide. But there might be an upside to this gas: in a new mouse study, it prevented clogged arteries:
⚡️Our April issue is out!⚡️With two papers from the TRACERx #LungCancer study, clinical trials in #Diabetes and #ProstateCancer, studies on salt substitution for lowering #BloodPressure and on #AI for #BrainCancer diagnosis, news, opinions, and much more! nature.com/nm/volumes/29/
Nature Medicine summarizes all the research you need to know this week on the #COVID19 pandemic. This week, read about the epidemiological analysis of 72 hospitals in Lombardy, Italy, where the ICU mortality rates were 26%. Free now, online. #Coronavirus go.nature.com/3ebfsVc
A #MachineLearning algorithm based on an array of demographic, physiological and clinical information is able to predict, hours in advance, circulatory failure of patients in the intensive-care unit #NMEDClinical
A cohort of asymptomatic patients infected with #SARSCoV2 had significantly lower levels of virus-specific IgG antibodies compared to a cohort of age- and sex-matched symptomatic infected patients. #COVID19 #asymptomatic #coronavirus #CQMU
go.nature.com/3eeaPJz
Nature Medicine is turning 25 this year! To kick off our 25th year, we've put together a focus issue on Digital Medicine. Check out the table of contents here: go.nature.com/2SF6Efi
GIF
A cross-sectional study of hospitalized patients with #COVID19 and a longitudinal follow-up study of patients with #COVID_19 suggest that #SARS_COV_2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset. #AntibodyTesting #Antibody.
On March 4, #WorldObesityDay, we at Nature Medicine and all journals @nresearchnews pledge to work together to help ending the #stigma of #obesity > go.nature.com/2IdGEEh #openaccess
Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but therapeutic benefit can be improved by combining with liver-directed #radiotherapy #metastasis #macrophages go.nature.com/38ccQp4
A randomized trial in Peru demonstrates population-wide reductions in blood pressure and risk of developing #hypertension after replacement of regular salt with a potassium-enriched alternative #NMEDClinical
Hi, I'm Joao Monteiro, chief editor and I'll be taking over the journal's account this week - follow me using the hashtag #NMEDtwittertakeover
A large, publicly available dataset integrating RNA, whole-exome, T cell receptor and 16S rRNA sequencing from patients with #ColonCancer enables the discovery of a #PrognosticScore consisting of tumor, immune and microbial features. #Microbiome #Tcell nature.com/articles/s4159
Implantation of a multielectrode paddle that allows personalized electrical stimulation to all regions of the spinal cord involved in leg and trunk movements rapidly restores motor function in spinal cord injury patients with complete paralysis
Single-cell #RNAseq identifies a gene signature associated with peripheral #monocyte populations that distinguishes people with #sepsis from those with sterile inflammation and uninfected controls #NMEDClinical
Single-cell transcriptome and T cell receptor analysis of bronchoalveolar lavage fluid suggests enrichment of proinflammatory macrophages in patients with severe #COVID19 and the presence of clonally expanded CD8+ T cells in those with moderate COVID-19.
The human heart contains 2 types of macrophages with distinct self-maintenance & inflammatory functions. An imbalance between these macrophage types correlates with left-ventricle remodeling & systolic function in patients w/heart failure: go.nature.com/2Qn3Odt #WorldHeartDay
A risk score developed using biological, psychological, and social factor data from the can predict different pain conditions and the prognosis of chronic pain up to 9-years later
A new study by Marisol Soengas, David Olmeda & cols, shows secretion of MIDKINE by #Melanoma cells modulates anti-tumor #Immunity and determines responses to #Immunotherapy in patients nature.com/articles/s4159 #Cancer #immunology
The human heart contains 2 types of macrophages with distinct self-maintenance & inflammatory functions. A shift in the balance between these macrophage populations correlates with left-ventricle remodeling & systolic function in patients w/heart failure: go.nature.com/2C9154K
"Designer probiotics" or "Probiotics 2.0" are taking center stage. Read more on these drugs in our newest feature: go.nature.com/2jlx2bX
A new study identifies four distinct neurophysiological biotypes of #depression from fMRI data from >1,000 patients: go.nature.com/2gUXeKe
EDITORIAL - Government officials who disseminate unsupported claims about the novel coronavirus undermine public trust in science and in the public-health efforts that are essential to bringing the #COVID19 pandemic under control > go.nature.com/2XzcP9I
The gut #microbiome of Irish Travellers, an ethnically distinct sub-population of Ireland, are similar to microbiomes of non-industrialized populations, but externally-imposed #lifestyle changes may alter their microbiota, with potential #health sequelae nature.com/articles/s4159
In a new strategy for increasing the availability of lungs for #transplantation, human lungs declined because of their poor quality can be recuperated within 24h by connecting them to the circulation of a pig nature.com/articles/s4159 #bioengeneering #physiology #biotechnology
In our latest Review: Multimodal #AI models could unlock many exciting applications in health and medicine; read about the most promising uses and technical pitfalls to avoid - from and
nature.com/articles/s4159
During the COVID-19 pandemic, the public have turned to scientists and doctors for vital information. But science communication is a skill in itself, so we asked the experts to share their tips.
Feature from
nature.com/articles/s4159
A smartphone app that combines smartwatch and activity tracker data together with self-reported symptoms allows continuous monitoring of #SARSCoV2 infection nature.com/articles/s4159 #COVID19 #wearables #bioengineering
After anti-PD-1 therapy in basal or squamous cell carcinoma patients, the CD8+ T cell response largely consists of an expanded and exhausted repertoire of new #Tcell clones | go.nature.com/2Onv7bi #ImmunoTherapy
The tumor immune microenvironment influences tumor progression and response to #immunotherapy; its further characterization will improve therapeutic outcome: go.nature.com/2KfA7Zy
COVID-19 boosters in rich nations will delay vaccines for all.
Correspondence from and
nature.com/articles/s4159
Single-cell analyses reveal type 1 conventional dendritic cells as conserved immunological drivers of non-alcoholic steatohepatitis in mice and humans.
nature.com/articles/s4159 #immunology #metabolicsyndrome
🌟 New Correspondence from and discussing the emergence of new #SARSCoV2 #variants and their effects on human immune responses.
nature.com/articles/s4159
Prophylactic use of anakinra, an IL-1 receptor inhibitor, reduced severe #neurotoxicity incidence in patients with r/r #lymphoma treated with anti-CD19 #CARTcells #immunotherapy
Adoptive T cell therapy induced complete and durable remission in a patient with refractory metastatic #breastcancer, providing proof of principle for this approach in breast cancer therapy: go.nature.com/2swsdDB #immunotherapy
Editorial: Genetic association studies of the human genome often omit the X chromosome, but a concerted effort to undo this exclusion could offer medically relevant insights into basic biology that might otherwise be missed: bit.ly/2AlHxrM
Overcoming Brazil’s monumental COVID-19 failure: an urgent call to action from nature.com/articles/s4159
The quest for new #antibiotics is forcing scientists to confront an old problem--the Gram-negative double membrane: go.nature.com/2hCbyeR
Scientists have followed the first patient to receive cells modified with #CRISPR–Cas9 genome editing technology for 19 months and not detected any major side effects. #GeneEditing go.nature.com/35yDHZd
#AI has the potential to reshape medicine, and the field is rapidly evolving.
In our latest Review, and colleagues discuss recent developments, challenges, and promising future directions
Proteins have long been drug targets, but scientists believe new targets can now be found in RNA. More in our story: go.nature.com/2pXUwKo
New study from researchers @sloan_kettering & shows the degree of sequence divergence between MHC Class I alleles influences the response of #Cancer patients to #Immunotherapy independently of tumor mutational burden nature.com/articles/s4159 #Genomics #immunoOncology
Randomized clinical trial shows antidiabetic effects of metformin are partially due to changes in the #microbiota: go.nature.com/2usy7FK
A single dose of a broadly neutralizing, HIV-specific antibody transiently reduces viral load in plasma, and in some individuals is associated with durable virus suppression in the absence of antiretroviral therapy
A review of 84 #COVID19 patients, receiving a combination of #Hydroxychloroquine and azithromycin, suggests an increased risk of drug-induced tachycardia. Particularly in those with co-morbidities. Read free online.
go.nature.com/2zNGkem
Analysis of the gut #microbiome from over 1,000 individuals in the PREDICT-1 study unveil new associations between specific microbes, #diet and cardiometabolic health.
Read the paper by
& colleagues 👉🏾nature.com/articles/s4159
As the pandemic shuts down labs across the globe, funders and institutions must step up to support scientists and ensure the healthy future of research.
Safeguard #research in the time of #COVID19. Read our latest editorial. go.nature.com/2RaavlR #free
The tumor immune #microenvironment influences tumor progression and response to #immunotherapy; its further characterization will improve therapeutic outcome: go.nature.com/2rMzCOd
A shift in the balance between the two distinct #macrophage populations in the human heart correlates with left-ventricle remodeling & systolic function in patients with #heartfailure: go.nature.com/2vJxE3O
This systematic comparison of ctDNA vs tissue sequencing by Ryan Corcoran, Gad Getz & cols. shows the superiority of liquid biopsy for capturing clinically relevant alterations mediating therapy resistance in #Cancer patients nature.com/articles/s4159 #PrecisionMedicine #Genomics
Systemic chronic #inflammation increases with age and is linked to the development of several diseases, as presented in this Perspective
Elevated levels of serum IL-6 and TNF-α at the time of hospitalization are independent and significant predictors of clinical outcome in two cohorts of patients with #COVID19 #biomarker
