Nathan Singh

@NathanSinghLab1

Focused on understanding how CARs control T cell function and dysfunction to engineer improved cellular immunotherapies for cancer.

St Louis, MO
Vrijeme pridruživanja: travanj 2019.

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  1. proslijedio/la je Tweet
    1. velj

    Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction | Cancer Discovery ⁦ |

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    Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction | Cancer Discovery

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  3. proslijedio/la je Tweet
    2. velj

    New paper from UPenn's proposing an explanation for primary resistance to (at least CD19) CAR Ts Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction

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  4. proslijedio/la je Tweet
    1. velj

    Resistance to - it’s your stupid: Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction

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  5. proslijedio/la je Tweet
    31. sij

    Resistance to CAR-T? It's your cancer, not your immune system — study – Endpoints News ⁦⁩ ⁦⁩ ⁦⁩ ⁦⁩ ⁦

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  6. proslijedio/la je Tweet
    30. sij

    Online today in : Impaired death-receptor signaling in causes antigen-independent resistance by inducing CAR-T cell dysfunction

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  7. proslijedio/la je Tweet
    30. sij

    Just published! Impaired death-receptor signaling in causes antigen-independent resistance by inducing CAR-T cell dysfunction

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  8. proslijedio/la je Tweet
    30. sij

    Why is tox lower in of / in ALL? - better management? - earlier Toci? - but especially earlier referral and fewer patients with highly refractory disease

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  9. 30. sij
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  10. proslijedio/la je Tweet
    30. sij

    In this study, we discovered that impaired death receptor signaling in leukemia causes antigen-independent resistance to CAR T cells by causing T cell dysfunction.

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  11. 30. sij

    So excited to share our paper from my time with out now in ! Ton of collaborative work: thanks to , Saar Gill, , and others . Check it out!

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  12. 27. sij

    More killer work coming out of the Mackall lab about dysfunction. Congrats and all the other stars on this exciting paper!

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  13. proslijedio/la je Tweet
    27. sij

    The 1st International Conference on Base Editing is kicking off now in beautiful Palm Springs. Thank you Reuben Harris, Catriona Jamieson, Alexis Komor, Branden Moriarity, and Matt Weitzman for organizing! 👏👏

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  14. proslijedio/la je Tweet
    26. sij

    Met-Flow: interrogation of active metabolic pathways in individual T cells by flow cytometry. Should try on pre-infusion vs f/up samples. Very cool.

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    20. sij

    Glypican-3-specific CAR T cells co-expressing IL15 and IL21 have superior expansion and antitumor activity against hepatocellular carcinoma

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  16. proslijedio/la je Tweet

    Sure. In neuroscience. I mean is there anything more truly hard to grasp than how some members of a species can produce incredible art, music, poetry, writing and science, while others emit unmitigated bullshit like this?

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  17. proslijedio/la je Tweet
    7. sij

    Pleased to announce my appointment for 2020 as Chair of the Professional Relations Committee

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  18. proslijedio/la je Tweet
    4. sij

    Cardiovascular Events Among Adults Treated With Chimeric Antigen Receptor T-Cells (CAR-T) | JACC: Journal of the American College of Cardiology

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    3. sij

    2020 will be the decade of cell therapy and genome engineering

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  20. 30. pro 2019.

    New review about mechanisms of failure out in Seminars in Cancer Biology! Great fun writing it with and colleagues. Lots of work to do to improve this platform!

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