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Multiple senior law enforcement officials briefed on the Pittsburgh synagogue mass shooting investigation tell @NBCNews that the suspect was armed with multiple guns.

Penn. Gov. Wolf: "Headed to the scene at Tree of Life Synagogue shooting. The suspect is in custody. We are providing local first responders with whatever help they need."

“There doesn’t seem to be much doubt here, as if there was any to start with, that this is a hate crime based on what we’re told by authorities the suspect said,” @PeteWilliamsNBC reports on @NBCNews Special Report.

Pittsburgh gunman entered synagogue, came out, engaged with police, and later came back out and was taken into custody, law enforcement sources tell @PeteWilliamsNBC, and the gunman had made anti-Semitic comments.

First Lady: My heart breaks over the news out of Pittsburgh. The violence needs to stop. May God bless, guide & unite the United States of America.

NYPD says it is deploying heavy weapons teams, including Critical Response Command and Strategic Response Team, to houses of worship across New York City as a precaution following Pittsburgh synagogue attack.

President Trump has departed the White House en route to an FFA event and a campaign rally in Indiana and Illinois.https://twitter.com/NBCNews/status/1056202625975308294 …

ADL CEO Jonathan Greenblatt: "We are devastated. Jews targeted on Shabbat morning at synagogue, a holy place of worship, is unconscionable. Our hearts break for the victims, their families, and the entire Jewish community."

Pittsburgh synagogue attack is "more devastating than originally thought," President Trump tweets, adding that he has informed the governor and mayor that the federal government "has been, and will be, with them all the way."

President Trump on synagogue shooting: “It’s a terrible, terrible thing what’s going on with hate in our country, frankly, and all over the world. And something has to be done.”

Canadian PM Trudeau: “Canadians’ hearts are with the Jewish community in Pittsburgh today, as they endured a horrific anti-Semitic attack while at prayer. May the families of those murdered be comforted, and may the injured recover quickly and fully.”

Pittsburgh public safety director says there at least 6 injuries, including 4 police officers, but declined, for now, to provide the number of deaths.

White House Press Sec. Sanders: "Saddened and appalled by the cowardly act of evil committed at Tree of Life Synagogue in Pittsburgh. We stand in total solidarity with the victims and all of the Jewish community against bigotry and hate."

Ivanka Trump: "All good Americans stand with the Jewish people to oppose acts of terror and share the horror, disgust & outrage over the massacre in Pittsburgh. We must unite against hated & evil."

President Trump says he spoke with Penn. Gov. Wolf, Pittsburgh Mayor Peduto, and Jared Kushner and Ivanka Trump about the Pittsburgh synagogue attack while en route to Indianapolis aboard Air Force One for an FFA event.

Naftali Bennett, Israeli minister of Education and Diaspora Affairs, will depart for US tonight to visit Pittsburgh synagogue attack scene, meet the community and participate in funerals: “The State of Israel is deeply pained by this terrible anti-Semitic murder." - @JoshNBCNews

ADL CEO Jonathan Greenblatt: “It is simply unconscionable for Jews to be targeted during worship on a Sabbath morning, and unthinkable that it would happen in the United States of America in this day and age.”

ADL CEO Jonathan Greenblatt: “This is likely the deadliest attack on the Jewish community in the history of the United States. We are actively engaged with law enforcement to support their investigation and call on authorities to investigate this as a hate crime.”

President Trump said he will attend Illinois campaign rally tonight after Pittsburgh synagogue attack today

Special agent in charge of Pittsburgh office of the FBI: We have no knowledge that suspect was known to law enforcement before today, says FBI believes he was acting alone.