Why aren’t clonally transmissible rumors ubiquitous? If they occur by nose contact in Tasmanian devils, why not by skin contact in most animals (including humans)?https://en.m.wikipedia.org/wiki/Clonally_transmissible_cancer …
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Replying to @The_Lagrangian
1) Cancer cells start as ordinary cells (thus by definition recognized by host immune system), and undergo constant selection to avoid the host's specific immune system as they mutate. Very unlikely to escape an entirely different immune system, bc no selection pressure.
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Replying to @St_Rev
Adam Strandberg Retweeted Adam Strandberg
Adam Strandberg added,
Adam Strandberg @The_LagrangianReplying to @The_Lagrangian @MemeArcanaimmunological genetic diversity can also be sufficiently low amongst humans to give viruses immunological “backdoors”, don’t see any reason why this wouldn’t also be true for transmissible cancers (specifically in the case of MHC) pic.twitter.com/LtZXCWbXba1 reply 0 retweets 0 likes -
Replying to @The_Lagrangian
This is getting kind of tedious. They could have happened. They didn't.
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Replying to @St_Rev @The_Lagrangian
I want to go meta on this point: * universe: rolls die * die: 5 turns up * people: "but why 5? That seems unlikely!" * me: <sigh>
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It is not obvious to me that the universe has in fact rolled a five- I suspect there are many more of these that we have yet to discover
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concur "we found it in dogs" - sounds like selection bias. What have we studied more? Man's best friend, or some random beetle from Bolivia?
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there is an argument to be made that adaptive immunity doesn’t matter from this perspective since species with adaptive immunity don’t have generally lower pathogen burden https://www.researchgate.net/publication/51370139_Hedrick_S_M_The_acquired_immune_system_a_vantage_from_beneath_Immunity_21_607-615 …
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