Problems two and three are a bit messier and more complicated than you imply here, but yeah. Hunger and appetite regulation gets into the interplay between metabolism (fiendishly complicated, poorly understood) and neural processes (ditto). We're learning but we don't know much.
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Similarly, depression is a psychological problem, but the most effective ways we have of treating it are all chemistry. ... but there are other ways, too, and they work, sometimes (just as the chemicals work, sometimes). It's messy and complicated.
End of conversation
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