Extremely excited to share the first major project from our lab, led by the brilliant @dpowell_daniel with major contributions from Mateo Garcia, Mackenzie Keegan, @lepatoptera, @pandolfatto, @gilrosenthal, Manfred Schartl, and other co-authors:https://biorxiv.org/cgi/content/short/2019.12.12.874586v1 …
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These melanin spots originate from one of the parental species (X. birchmanni). Histology and gene expression showed that in hybrids some of these spots had become malignant melanomas. In some hybrid populations, rates of melanomas reached ~20%.
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We used a variety of approaches to fine map the genes involved in this incompatibility, ultimately identifying an interaction between cd97 and xmrk. This was surprising because xmrk causes melanoma in a distantly related swordtail cross, that does not hybridize in the wild.
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We also found evidence for strong viability selection against the melanoma incompatibility in natural hybrid populations. Puzzlingly, the melanoma is maintained at moderate frequencies in some populations, which we are excited to dig into in future work.
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