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A new thread about a series of papers in legitimate scientific journals, all from the same author. These papers have all been peer-reviewed, but no editor or peer reviewer noticed a huge problem. Warning: this might make your jaw drop.
Let's start with the most recent paper of this set that I could find. Here it is: "YXQ-EQ Induces Apoptosis and Inhibits Signaling Pathways Important for Metastasis in Non-Small Cell Lung Carcinoma Cells" https://www.karger.com/Article/FullText/493223 …pic.twitter.com/zwYwTBCYBy
It is about "YXQ-EQ" that can inhibit lung cancer cells.
At first glance that sounds amazing. And although it was not published in a grand journal, some of the authors are from @Harvard, @BrighamResearch, and @DanaFarber - so it must be excellent research, right?
So, what is this magical compound "YXQ-EQ", you might ask. Excellent question. Let's look at the abstract.pic.twitter.com/oKkT4Im3Zm
"This study was aimed to investigate cytotoxic effect of external qi of Yan Xin Qigong (YXQ-EQ) toward human lung adenocarcinoma A549 cells". Mmm, that sounds a bit vague. What is it, exactly? The introduction text does not help a lot, either.pic.twitter.com/TKUcuqbwPW
I want to stress here that it is not my intention to make fun of traditional Chinese Medicine. There are many good medical therapies based on TCM. Here, I am specifically investigating the "YXQ-EQ" method.
Let's take a look at the Methods section. Surely, we will learn more about how the researchers treated the cells with "YXQ-EQ". After all, the Methods section of a scientific paper should have enough detail so that other researchers can reproduce the study.pic.twitter.com/xg9ZZ397Ed
There is nothing in the methods about the "YXQ-EQ" treatment. Let me repeat that, so it is very clear: nothing. No "Briefly, this involved...". No reference. Only that it lasted 5 minutes.
A good reviewer should have asked for a detailed description of the magical treatment.
If not given by authors in revised manuscript, that is reason to reject. That is the strength of #PeerReview.
Apparently, none of the reviewers/editors asked this question.
Yet, this elusive method has great powers. It magically kills cancer cells, so how does it work? Let's look at the references about the "YXQ-EQ" method. There is a lot of self-citation going on here. Another red flag.pic.twitter.com/cffu1mVav9
Another red flag: the corresponding author, from @Harvard / @DanaFarber does not list their institutional email. That does not necessarily mean anything (people hop around and so emails change), but I consider this a red flag here.pic.twitter.com/Nm62D7bCij
Let's take a look at some of the other references about the mysterious "YXQ-EQ" treatment. I suddenly realize that "Yan Xin Qigong" refers to the name of the first author. It is his method, and only Dr. Yan Xin has written about it.
There is another paper (same journal) by Dr. Yan Xin, in which "YXQ-EQ" inhibits colon cancer cells. "External Qi of Yan Xin Qigong Inhibits Activation of Akt, Erk1/2 and NF-kB and Induces Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells"https://www.karger.com/Article/FullText/343354 …
In a third paper, from 2012, "YXQ-EQ" inhibits growth of another cell line of lung cancer. https://link.springer.com/article/10.1007%2Fs11010-011-1176-8 …pic.twitter.com/yS25tKDdff
Apologies, I somehow broke this threat by replying to the wrong tweet. Read the continuation here:https://twitter.com/MicrobiomDigest/status/1131681481112182784 …
Not commenting on effects of external Qi (energy) cancer cells, but I want to point out that qigong is a widely practiced form of exercise in China and the authors may have felt it self explanatory. One would not be expected to explain a widely practiced western exercise.
Agreed, but many people (including me) are very unfamiliar. The reviewers should have called out for a detailed description, like researchers have to do for other techniques, such as Western blots, PCR, or bioinformatic analysis. Science should be reproducible.
But it's not just qigong. It's "Yan Xin Qigong". No one could be expected to know what that means, other than Yan Xin. I wouldn't be expected to explain "push-ups" but I would expected to explain "Michael Hoffman Push-ups".
Great analogy. Also, I would love a good explanation of general push-ups. I am always completely bewildered at the gym.
I just do them as described previously.
Hope this helps! 
Manuscript approved for publication. Signed: reviewer 2.
I attempting the @michaelhoffman push-up protocol.
How many cats do you need? Are two sufficient?
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