Pop-up ads: wait a few seconds before appearing, hard-to-find close buttons, fade slowly or move around screen. Please-remove-your-ad-blocker-popups: none of those problems, but make you feel guilty. Overall kind of a tie at this point, just as Econ 101 would predict.
You've not seen the Ad Blocker pop ups that are hard to close, wait a few seconds, or requite whitelisting to get rid of yet then. I'm in Digital Marketing (I'm sorry! I work for non-profits!) and even I find this to be...impressive.