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  1. Retweeted
    20 Nov 2019

    This week on the Nature cover: Waves of mutation. Barcode system images evolutionary dynamics of laboratory yeast. Browse the issue here:

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  2. Retweeted

    Over the next couple of days, I'll describe some of the essential components of our technology and how they make long term lineage tracking possible, including: A novel, hyper-directional, set of Lox sites Reiterative Cre-Lox cassette exchange The splicing trap

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  3. Retweeted

    and I spent years tracking down rebellious cells that refused to acquire new barcodes. We analyzed how they managed to escape our selections and redesigned our system again and again to try to lead them in the right direction.

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  4. Retweeted

    The same argument applies to cells that acquire the ability to circumvent selection during gene stacking. The minor flaws of technologies in synthetic biology seem to limit our ability to create complex combinations of simpler constructs.

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  5. Retweeted

    In a traditional DNA barcoding applications, rare cells that acquire the ability to circumvent barcoding selection are not a big issue. In our case, these rebellious cells would be fatal, since they would have a huge advantage during the next round of barcode addition.

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  6. Retweeted

    This fusion of these technologies allows us to sequentially add random DNA barcodes into an evolving population to create a time-sorted barcode array at a specific locus in each cell. Earlier barcodes on this array identify more distant ancestors.

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  7. Retweeted

    Our technique is an attempt to recombine two existing technologies, high resolution DNA barcoding (see ), and gene stacking (e.g. ).

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  8. Retweeted

    Here's a thread telling the story of our new technique for genetic recording of lineage history during long term evolution experiments. The work was co-led with and in 's lab. Read the paper here:

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  9. Retweeted

    What does evolution look like? We developed a rebarcoding approach to observe the travelling wave of adaptation at extremely high resolution. See short summaries by co-authors , in the lab of . Read the paper here:

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  10. Retweeted
    13 Nov 2019

    What do you expect evolution to look like in a microbial population? Check out our new study offering a view of that over 1000 generations in yeast in the lab. co-led by , , in 's lab

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  11. Retweeted
    24 Oct 2019

    Our Tn-Seq paper with , Alena Martsul and is out in . Accompanied by a nice perspective by Craig Miller with a cool fitness landscape: Here is my original summary:

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  12. Retweeted
    20 Jun 2019

    Our new preprint “Higher fitness yeast genotypes are less robust to deleterious mutations” is out. , an amazing PhD student in lab, led this collaborative work. Alena Martsul from my lab also contributed. Please provide feedback!

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  13. Retweeted
    30 Dec 2018

    End-of-year rant: Soft sweeps (equivalent adaptations arising independently multiple times) are common in RNA viruses. Stirring up a debate on this non-issue using simplistic models and dubious parameters is a waste of time. More here:

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  14. 8 Nov 2018

    Work led by Dan Rice (and in collaboration w/) on signatures of non-Kingman coalescence

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  15. Retweeted
    29 May 2018

    How does strong background selection influence the site frequency spectrum? Our paper published today online at explains. With and .

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  16. Retweeted
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  17. Retweeted
    30 Oct 2017

    Our new preprint on the signatures of strong background selection is now available!

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  18. Retweeted
    30 Aug 2017

    Some sequencing in challenging environment: theoretical physics institute

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  19. 24 Apr 2016

    Very sad to hear about Paul Joyce. He was a fantastic colleague, always great to talk to, I learned a lot from him and from his work

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