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Better than ever...maybe it’s the fly connectome cookies!
@janeliaflyempic.twitter.com/NA1xYx8n65
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Would you like to figure out how smart flies are by developing new behavioral methods (like visual place learning, below)? We are looking for a new postdoc to join us: https://www.janelia.org/lab/reiser-lab/positions … If interested and at
#SICB2020 -- let’s talk ASAP [RT appreciated!]pic.twitter.com/muOYL8iga7 -
A conductance model using fast excitation and slow trailing inhibition is far superior to either a linear model or a conductance model using the removal of excitation (5/5)pic.twitter.com/bflGYRq6Ib
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Then we turn to a computational analysis…a conductance model fit ONLY using simple flashing bar responses accurately predicts the response dynamics even for complex moving stimuli (4/5)pic.twitter.com/vz9g0ipx0Z
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Yet again, we find no evidence for a Reichardt-like mechanism. We never see enhanced responses to Preferred Direction motion (the red quadrant is empty!) (3/5)pic.twitter.com/DUAbakKEyw
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Directional selectivity in the ON and OFF pathways is computed using the same algorithm despite different circuitry (2/5)pic.twitter.com/t5FpISaVmf
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Excited to announce our latest paper! Last year
@EGruntman and@ratecoding ‘cracked’ the algorithm for how the ON directionally selective neurons compute motion. Now they’ve done it for the OFF pathway (1/5) https://doi.org/10.7554/eLife.50706 …@eLife [T4/T5 image from Aljoscha Nern]pic.twitter.com/SDRHEROvVy
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The obvious tool for the job is a ‘pickle pincher’ — but it is worth the time/money to order one?pic.twitter.com/KmtThLJgFy
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We are hiring a postdoc for a super exciting position in Neural Circuits and Behavior! Join us in figuring out how vision 'turns into' behavior: https://janelia.org/lab/reiser-lab/positions … Please RT. [
@catmaid image showing one pathway we are excited about for visual motion into central brain]pic.twitter.com/5JmIaIYPGQ
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Our latest from
@EGruntman &@ratecoding. Whole cell recordings from OFF directionally selective T5 neurons. T5s compute motion by integrating fast excitation with slow, trailing inhibition (like T4). No amplification of PD motion. Ends w. exciting update on motion models! https://twitter.com/biorxivpreprint/status/1157408119867301888 …pic.twitter.com/shRpnUC2MO
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Getting ready for
@CSHLflycourse! On Saturday@fra_loe and I will try to demystify fly on ball behaviors. It’s been great fun to make this setup cheap and simple. More details soon. Now some pics: fly holder, printing ball holders, mounting manipulators, wiring up peltierpic.twitter.com/kiqc1BtzQu
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Today demoed a machine vision system, usually used for parts inspection, so maybe flies? It does multi-spectral imaging, 8 pics in sequence each illuminated w different wavelength. Fun movies, but sadly we didn’t discover any fly parts that look amazing under special wavelengthspic.twitter.com/dGzjQDxdJd
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I always appreciate error bars in unexpected places...(Berlin U-Bahn on the way to connectomics conference)pic.twitter.com/3VbqqeFn37
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#dros19 people -- interested in using expansion microscopy to explore neural circuit properties? come see poster by Ed Rogers #661 starting this afternoon (3pm); poster preview tomorrow (10 am). Data below is from Ed...ask him for all the details!pic.twitter.com/iRxNdPKctl -
Very pleased with this inexpensive XYZ linear stage...I got this one on Amazon for $139, and later found even cheaper on eBay. Only hassle was adapting it to imperial breadboard. I think these will be very handy for positioning cameras, flies, etc.pic.twitter.com/1evgJYcoVK
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The ‘wall of screws’ at
@HHMIJanelia saves the day again!!pic.twitter.com/Sx0wBvGu8E
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This diagram (e.g. from Yang and Clandinin) will certainly make the point that many of the details are now known. How we get from connectivity of these cells to the functional transformation in T4/T5 neurons remains controversial/unresolved, so no great synthesis yet.pic.twitter.com/Q8wop8ItGp
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Flying Drosophila VR by Matt Isaacson (yaw+pitch control, UV 'sky'). We’ve designed an extremely powerful visual display system — fast, modular, multi-color (w UV!) — now ready to roll it out. Matt presents a dynamic poster Sunday 11/4, 8 am - noon (DP07, 144.01)
#SfN18pic.twitter.com/j4GLtWpzXa -
there are many exciting new findings contained in these data -- a few neat stories are included: R8 photoreceptors release ACh in addition to histamine! Evidence that GABA may excite monopolar cells! and more…pic.twitter.com/AzRXPUZJ6I
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among other great new results, we finally know the transmitters for many cells! Including all of the principal neurons of the motion pathway. As suspected, small-field T4 inputs turn out to include ACh, GABA, and Glu, while T5 small-field inputs are only AChpic.twitter.com/bf3GP3gyGd
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