Skip to content
By using Twitter’s services you agree to our Cookies Use. We and our partners operate globally and use cookies, including for analytics, personalisation, and ads.
  • Home Home Home, current page.
  • About

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @
  • Language: English
    • Bahasa Indonesia
    • Bahasa Melayu
    • Català
    • Čeština
    • Dansk
    • Deutsch
    • English UK
    • Español
    • Filipino
    • Français
    • Hrvatski
    • Italiano
    • Magyar
    • Nederlands
    • Norsk
    • Polski
    • Português
    • Română
    • Slovenčina
    • Suomi
    • Svenska
    • Tiếng Việt
    • Türkçe
    • Ελληνικά
    • Български език
    • Русский
    • Српски
    • Українська мова
    • עִבְרִית
    • العربية
    • فارسی
    • मराठी
    • हिन्दी
    • বাংলা
    • ગુજરાતી
    • தமிழ்
    • ಕನ್ನಡ
    • ภาษาไทย
    • 한국어
    • 日本語
    • 简体中文
    • 繁體中文
  • Have an account? Log in
    Have an account?
    · Forgot password?

    New to Twitter?
    Sign up
Meaningness's profile
David Chapman
David Chapman
David Chapman
@Meaningness

Tweets

David Chapman

@Meaningness

Better ways of thinking, feeling, and acting—around problems of meaning and meaninglessness; self and society; ethics, purpose, and value.

meaningness.com/about-my-sites
Joined September 2010

Tweets

  • © 2020 Twitter
  • About
  • Help Center
  • Terms
  • Privacy policy
  • Imprint
  • Cookies
  • Ads info
Dismiss
Previous
Next

Go to a person's profile

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @

Promote this Tweet

Block

  • Tweet with a location

    You can add location information to your Tweets, such as your city or precise location, from the web and via third-party applications. You always have the option to delete your Tweet location history. Learn more

    Your lists

    Create a new list


    Under 100 characters, optional

    Privacy

    Copy link to Tweet

    Embed this Tweet

    Embed this Video

    Add this Tweet to your website by copying the code below. Learn more

    Add this video to your website by copying the code below. Learn more

    Hmm, there was a problem reaching the server.

    By embedding Twitter content in your website or app, you are agreeing to the Twitter Developer Agreement and Developer Policy.

    Preview

    Why you're seeing this ad

    Log in to Twitter

    · Forgot password?
    Don't have an account? Sign up »

    Sign up for Twitter

    Not on Twitter? Sign up, tune into the things you care about, and get updates as they happen.

    Sign up
    Have an account? Log in »

    Two-way (sending and receiving) short codes:

    Country Code For customers of
    United States 40404 (any)
    Canada 21212 (any)
    United Kingdom 86444 Vodafone, Orange, 3, O2
    Brazil 40404 Nextel, TIM
    Haiti 40404 Digicel, Voila
    Ireland 51210 Vodafone, O2
    India 53000 Bharti Airtel, Videocon, Reliance
    Indonesia 89887 AXIS, 3, Telkomsel, Indosat, XL Axiata
    Italy 4880804 Wind
    3424486444 Vodafone
    » See SMS short codes for other countries

    Confirmation

     

    Welcome home!

    This timeline is where you’ll spend most of your time, getting instant updates about what matters to you.

    Tweets not working for you?

    Hover over the profile pic and click the Following button to unfollow any account.

    Say a lot with a little

    When you see a Tweet you love, tap the heart — it lets the person who wrote it know you shared the love.

    Spread the word

    The fastest way to share someone else’s Tweet with your followers is with a Retweet. Tap the icon to send it instantly.

    Join the conversation

    Add your thoughts about any Tweet with a Reply. Find a topic you’re passionate about, and jump right in.

    Learn the latest

    Get instant insight into what people are talking about now.

    Get more of what you love

    Follow more accounts to get instant updates about topics you care about.

    Find what's happening

    See the latest conversations about any topic instantly.

    Never miss a Moment

    Catch up instantly on the best stories happening as they unfold.

    1. St. Rev  ☯️ 🏴 😻‏ @St_Rev 7 Feb 2018
      • Report Tweet
      • Report NetzDG Violation

      St. Rev  ☯️ 🏴 😻 Retweeted Nick Wing

      No no no no no GOD no. A computer model, at best, gives you a lead to start trials. You don't label something an X agonist because the model says so!https://twitter.com/nickpwing/status/960952612551118848 …

      St. Rev  ☯️ 🏴 😻 added,

      Nick WingVerified account @nickpwing
      .@US_FDA gives update on its review of kratom. A few takeaways: Using a new computational model, the agency feels "confident in calling compounds found in kratom, opioids." pic.twitter.com/P3N9gzLgcK
      Show this thread
      3 replies 4 retweets 16 likes
      David Chapman‏ @Meaningness 7 Feb 2018
      • Report Tweet
      • Report NetzDG Violation
      Replying to @St_Rev

      It’s much worse than that. If a computer model said Y might be an X agonist, the first thing you do is see whether it even binds to the purified receptor in vitro. That is cheap & quick & easy.

      8:10 PM - 7 Feb 2018
      • 2 Retweets
      • 12 Likes
      • Content of Media Soham Chowdhury Alberto Albero 🌲 Kevin crepuscular dispatch Krill la Krill sol Jay Kominek James Tinged Words
      2 replies 2 retweets 12 likes
        1. New conversation
        2. David Chapman‏ @Meaningness 7 Feb 2018
          • Report Tweet
          • Report NetzDG Violation
          Replying to @Meaningness @St_Rev

          Typically you can do an in vitro assay in minutes or hours, at a cost of a few dollars per compound. Quick googling suggests the opioid receptors are not an exception. That they didn’t report in vitro results ends to suggest that they in fact did the assay and found no binding.

          1 reply 2 retweets 9 likes
        3. David Chapman‏ @Meaningness 7 Feb 2018
          • Report Tweet
          • Report NetzDG Violation
          Replying to @Meaningness @St_Rev

          OK, tbf, it’s a transmembrane receptor, so you can’t assay against the purified protein. You have to use live cells, which is a bit of a pain. But it’s an off-the-shelf procedure you can buy in a package: https://assets.thermofisher.com/TFS-Assets/BID/Product-Guides/081-01.03_MOR1-PKA_RAP_LC06963402.pdf … No excuse for not actually doing the experiment.

          0 replies 2 retweets 3 likes
        4. End of conversation
        1. New conversation
        2. Srijit Sanyal‏ @_Srijit 7 Feb 2018
          • Report Tweet
          • Report NetzDG Violation
          Replying to @Meaningness @St_Rev

          does the FDA ever do competent things as well, sometimes? I only ever see negative takes on them.

          1 reply 0 retweets 0 likes
        3. St. Rev  ☯️ 🏴 😻‏ @St_Rev 8 Feb 2018
          • Report Tweet
          • Report NetzDG Violation
          Replying to @_Srijit @Meaningness

          I think the consensus among the lunatics I listen to is that they do more harm than good because their institutional incentives are misaligned -- they are punished for allowing bad medicines, but not for forbidding good ones, roughly.

          1 reply 0 retweets 0 likes
        4. 1 more reply

      Loading seems to be taking a while.

      Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.

        Promoted Tweet

        false

        • © 2020 Twitter
        • About
        • Help Center
        • Terms
        • Privacy policy
        • Imprint
        • Cookies
        • Ads info