No no no no no GOD no. A computer model, at best, gives you a lead to start trials. You don't label something an X agonist because the model says so!https://twitter.com/nickpwing/status/960952612551118848 …
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Typically you can do an in vitro assay in minutes or hours, at a cost of a few dollars per compound. Quick googling suggests the opioid receptors are not an exception. That they didn’t report in vitro results ends to suggest that they in fact did the assay and found no binding.
OK, tbf, it’s a transmembrane receptor, so you can’t assay against the purified protein. You have to use live cells, which is a bit of a pain. But it’s an off-the-shelf procedure you can buy in a package: https://assets.thermofisher.com/TFS-Assets/BID/Product-Guides/081-01.03_MOR1-PKA_RAP_LC06963402.pdf … No excuse for not actually doing the experiment.
does the FDA ever do competent things as well, sometimes? I only ever see negative takes on them.
I think the consensus among the lunatics I listen to is that they do more harm than good because their institutional incentives are misaligned -- they are punished for allowing bad medicines, but not for forbidding good ones, roughly.
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