Selective Serotonin Rewait what http://j.mp/OKt7WU
@St_Rev Not really—the issue in this case is target selection (i.e. serotonin) rather than “rational” (i.e. receptor binding model).
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@Meaningness On further thought I'm going back way off all my claims here. -
@St_Rev Well, fwiw, your general point, that drug r&d is fxd, seems right to me. - 2 more replies
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@Meaningness What I mean is, picking compounds to hit X, then 20 years later finding that hitting X has nothing to do with the mechanism...Thanks. Twitter will use this to make your timeline better. UndoUndo
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@Meaningness ...suggests you might just as well have picked compounds randomly, screened for toxicity, then looked for clinical activity.Thanks. Twitter will use this to make your timeline better. UndoUndo
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@Meaningness That's how they did it in the good old days, minus the toxicity screening, and look at all the cool drugs we got!Thanks. Twitter will use this to make your timeline better. UndoUndo
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@Meaningness sorry replied to this tweet w/o reading subsequent tweetsThanks. Twitter will use this to make your timeline better. UndoUndo
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