i am confused as to why remdesivir would specifically target viral genome replication if it's just an adenosine analogue
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Replying to @Meaningness
so the explanation is "it just happens to have exactly the right shape idk"- there's biology for you
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Replying to @The_Lagrangian
I don’t think so, although maybe I’m missing something? If you hang random junk off a nucleoside, it’s pretty likely to screw up the polymerase.
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Replying to @Meaningness
yes but they don't appear to have a hypothesis about the differences between viral + human RNA polymerase that make the specificities differ
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Replying to @The_Lagrangian
This is almost always the case I think? You get specificity by random hill climbing. Add a methyl, subtract a methyl, measure and repeat.
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Replying to @Meaningness @The_Lagrangian
In other words, you find something that happens to bang into some bit of the human polymerase but doesn’t bang into the viral one because the latter has a void there.
1 reply 0 retweets 3 likes
(“Something” = a sidechain)
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