i am confused as to why remdesivir would specifically target viral genome replication if it's just an adenosine analogue
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In other words, you find something that happens to bang into some bit of the human polymerase but doesn’t bang into the viral one because the latter has a void there.
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(“Something” = a sidechain)
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SAR, baby sometimes it's a little more thoughtful than that, if you have a structure and some idea of important contacts or what have you but yeah many times it's methyl ethyl futile rinse and repeat
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it's pretty astonishing this ever works given the size of the search space
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