i am confused as to why remdesivir would specifically target viral genome replication if it's just an adenosine analogue
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yes but they don't appear to have a hypothesis about the differences between viral + human RNA polymerase that make the specificities differ
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This is almost always the case I think? You get specificity by random hill climbing. Add a methyl, subtract a methyl, measure and repeat.
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The iterative optimization steps would be to get the IC50 down, make sure it gets to where it needs to go (not too lipophilic etc), and selective for virus/human polymerase. Pretty standard medchem analoguing Iexpect
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