The synthesis shown in the wiki article doesn’t look scalable (but finding better routes might be straightforward, I have no idea, I’m not a chemist) https://en.wikipedia.org/wiki/Remdesivir
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I hope every medicinal and process chemist is putting any spare time thinking into how to make remdesivir in bulk.
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Ah! This is encouraging: looks like the bulk synthesis pathway has been worked out. h/t
@ajkirby01 https://www.who.int/ebola/drc-2018/summaries-of-evidence-experimental-therapeutics.pdf?ua=1 …pic.twitter.com/8puATBXKvd
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Tried to find some adverse event data for remdesivir, tbh looks pretty good. https://www.who.int/ebola/drc-2018/summaries-of-evidence-experimental-therapeutics.pdf?ua=1 …
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Seems to be the most promising candidate https://apps.who.int/iris/bitstream/handle/10665/330680/WHO-HEO-RDBlueprint%28nCoV%29-2020.1-eng.pdf?ua=1 …pic.twitter.com/5NhOk0FmG8
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Mm, chloroquine pretty brutal too. Had a conversation with a Japanese prof about it recently - virtually banned there due to irreversible retinopathy side-effect
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