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Meaningness's profile
David Chapman
David Chapman
David Chapman
@Meaningness

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David Chapman

@Meaningness

Better ways of thinking, feeling, and acting—around problems of meaning and meaninglessness; self and society; ethics, purpose, and value.

meaningness.com/about-my-sites
Joined September 2010

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    1. Adam Strandberg‏ @The_Lagrangian 16 Aug 2019
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      What if instead we just identified a gene coding for an antibody that works, and directly modified your B cells to do that?

      2 replies 0 retweets 2 likes
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    2. Adam Strandberg‏ @The_Lagrangian 16 Aug 2019
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      This turns out to be feasible using CRISPR/Cas9. You can insert a gene coding for a specific antibody region in a location that silences expression of whatever antibody the B cell previously coded for

      1 reply 0 retweets 5 likes
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    3. Adam Strandberg‏ @The_Lagrangian 16 Aug 2019
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      The location is also relatively constant across people (contains no SNPs with >1% prevalence), so it’s a good target

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    4. Adam Strandberg‏ @The_Lagrangian 16 Aug 2019
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      There are some difficulties though, not the least of which is somatic hypermutation- B cells introduce random mutations to the genes encoding antibodies (in order to have the diversity the adaptive immune system is famous for)-means the engineered cells could become self-reactive

      1 reply 0 retweets 3 likes
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    5. Adam Strandberg‏ @The_Lagrangian 16 Aug 2019
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      Research into suppressing somatic hypermutation in these cells would be super useful imo, interesting to see whether you could do it with another CRISPR knockout

      1 reply 0 retweets 4 likes
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    6. Adam Strandberg‏ @The_Lagrangian 16 Aug 2019
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      Then of course there are the infamous off-target mutations in CRISPR systems. There seems to be a legion of people working on that so if it’s possible to fix I’m confident it will be

      1 reply 1 retweet 4 likes
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    7. Adam Strandberg‏ @The_Lagrangian 16 Aug 2019
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      And finally cost- CAR-T is a similar therapeutic strategy involving custom-modifying T cells from the patient and costs about $100k

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    8. David Chapman‏ @Meaningness 16 Aug 2019
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      Replying to @The_Lagrangian

      Presumably this can be brought way down if scaled up? unless someone gets in the way of that

      1 reply 0 retweets 2 likes
    9. will minshew‏ @wminshew 16 Aug 2019
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      Replying to @Meaningness @The_Lagrangian

      yeah have either of you come across estimates on the actual variable cost for these procedures? (I assume the price is mostly amortized drug portfolio r&d)

      1 reply 0 retweets 0 likes
    10. Adam Strandberg‏ @The_Lagrangian 16 Aug 2019
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      Replying to @wminshew @Meaningness

      CAR-T is very new so it is a combo amortized R&D and leveraging willingness-to-pay with principal-agent problems. Misremembered the price though, it's $500k for the drug with >$500k in expected associated costshttps://www.healio.com/hematology-oncology/cell-therapy/news/online/%7B124396e7-1b60-4cff-a404-0a2baeaf1413%7D/car-t-cell-therapy-total-cost-can-exceed-15-million-per-treatment …

      2 replies 0 retweets 0 likes
      David Chapman‏ @Meaningness 16 Aug 2019
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      Replying to @The_Lagrangian @wminshew

      Lab techs are not expensive. The genuine cost if scaled can’t amount to much. The question is whether the system will allow that.

      7:31 PM - 16 Aug 2019
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      • will minshew Sarah Constantin Adam Strandberg
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        2. halvorz is cheating on Lentmoot with SARS-2‏ @halvorz 16 Aug 2019
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          Replying to @Meaningness @The_Lagrangian @wminshew

          Scaling will help, but it will likely take some genuine technical developments to bring costs down a lot.https://www.quora.com/Is-the-cost-of-testing-approving-and-manufacturing-gene-therapy-drugs-going-down-so-that-miracle-drugs-like-Glybera-can-be-commercially-viable-soon …

          1 reply 0 retweets 2 likes
        3. David Chapman‏ @Meaningness 16 Aug 2019
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          Replying to @halvorz @The_Lagrangian @wminshew

          Really interesting, thank you! Geez, this made me want to immediately do 237 web searches, and then start a company

          2 replies 0 retweets 3 likes
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