Worth keeping in mind that, as with any pharmaceutical treatment, psychological practices may also have side effects: https://aeon.co/essays/mindfulness-is-loaded-with-troubling-metaphysical-assumptions … (@meaningness - I think you've argued that the issues she raises are found more with sutra than tantra?)
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This doesn’t imply that Vajrayana is safe; it isn’t. But depersonalization, derealization, depression, and nihilism (loss of meaning) are not common bad outcomes from Tantra. Those are common bad outcomes from Sutra.
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