In many areas, there is a 'brute force' approach. It's often pretty unpopular. Doesn't mean it's wrong, though... [genetics/statistics/AI/economics/politics-ethics/philosophy/science] :: [bigger GWASes/Monte Carlo/more GPUs/capitalism/economic growth/atomism/reductionism].
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What? When was biology *ever* 'simple tiny meat bits all the way down'? Certainly not Aristotle, or preformationism, or anything.
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Fair; that was an exaggeration. But there’s been frequent addition of large complex entities that were previously unsuspected. (But those aren’t ontologically basic, per your spec. What are examples of complex ontologically basic objects?)
End of conversation
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As far as I can remember, microtubules came after I did grad-level cellular bio in early 80s, and I was taught there was just undifferentiated “cytosol,” although that may be wrong.
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