We can’t accurately simulate the physical behavior even of pure water. (Yet; and from other reading about this I’ve done recently, it’s a long way off.) Therefore: Fantasies about simulating brains are fantastical.https://twitter.com/ashleythesmart/status/1032294373382340608 …
I am not a chemist. OTOH I have worked professionally in molecular modeling, and have multiple publications and patents in the field, so I’m not completely ignorant. My knowledge is quite out of date, so I’ve been interested to learn a bit about the state of art for water models.
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Because you don't use "accurately" accurately, you collapse all the relevant distinctions. We can model water on many different levels to differing degrees of accuracy.
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It is quite true that at the quantum level our models are less accurate and certainly less precise. But that does not equate to what you initially said "We can’t accurately simulate the physical behavior even of pure water."
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You are not making a clear distinction between levels of knowledge, and particularly between philosophy and science.
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