We can’t accurately simulate the physical behavior even of pure water. (Yet; and from other reading about this I’ve done recently, it’s a long way off.) Therefore: Fantasies about simulating brains are fantastical.https://twitter.com/ashleythesmart/status/1032294373382340608 …
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Water is a knock-down argument against reductionism as a theory of how rationality works. It’s astonishing what we DON’T know about water. We can’t even simulate individual isolated water molecules accurately. http://www1.lsbu.ac.uk/water/water_molecule.html …pic.twitter.com/TXhrCsw5HP
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Replying to @Meaningness
I know this is rhetorical, but still, you cannot use "accurately" as an absolute. We *can and do* simulate water molecules to *some degree* of accuracy & precision ± error. What level of accuracy are you suggesting vitiates reductionism? Or do you mean precision?
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Replying to @Jayarava
In this case, “accurately enough to qualitatively predict simple intermolecular processes,” eg
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Replying to @Meaningness @Jayarava
Still, we keep polishing the turd and it gets a bit shinier each time - http://www.pnas.org/content/early/2018/05/02/1800690115 …
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Replying to @gomijacogeo @Jayarava
Are you working in this field now? I used to work with CHARMM and Amber (the systems used in the paper). Nice to see incremental progress. Have some skepticism about details, but my knowledge is 20 years out if date.
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Replying to @Meaningness @Jayarava
No. I did some porting and tuning work on these and other codes for SGI back in the mid-90's (and folding@home). The rest is just amateur interest. But I knew D. E. Shaw has been big on making water models better and faster, so I had an idea where to look.
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Ah. I was running them on SGIs in mid-90s, so probably using your code! Small world!
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