We can’t accurately simulate the physical behavior even of pure water. (Yet; and from other reading about this I’ve done recently, it’s a long way off.) Therefore: Fantasies about simulating brains are fantastical.https://twitter.com/ashleythesmart/status/1032294373382340608 …
In this case, “accurately enough to qualitatively predict simple intermolecular processes,” eg
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In all my years of doing chemistry, I never had much trouble knowing what atoms or molecules would do or the kinds of processes that they would undergo.
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Well, I don’t know if you followed the links, but both are to discussions of pretty basic things about water that are not understood. Apparently there are many such. A lot of this has to do with its transient hydrogen-bonded multimers: http://www1.lsbu.ac.uk/water/water_hydrogen_bonding.html …
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Nb I’m not making any in-principle metaphysical statement here. Rather, observing that rationality does often work in circumstances in which reduction is not currently practical or practiced; so reduction cannot be the explanation for why rationality works.
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But you *have made* a metaphysical statement. I understand if that is not what you intended, but it is what you *did*.
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Still, we keep polishing the turd and it gets a bit shinier each time - http://www.pnas.org/content/early/2018/05/02/1800690115 …
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Are you working in this field now? I used to work with CHARMM and Amber (the systems used in the paper). Nice to see incremental progress. Have some skepticism about details, but my knowledge is 20 years out if date.
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