Despite the wide and growing use of VNS, the mechanisms underlying its clinical benefits are still largely unknown, and there is a lack of biosensors for assaying stimulation efficacy in real time.
-
-
Prikaži ovu nit
-
We developed an approach to VNS in head-fixed mice on a treadmill, and use it to show that pupil dilation parametrically scales with the electrical parameters of stimulation.pic.twitter.com/WN4s4DWDmY
Prikaži ovu nit -
Further, parametrically varying VNS resulted in titratable release of acetylcholine in cortex.pic.twitter.com/NnVPOluvek
Prikaži ovu nit -
Path analysis indicated that the extent to which VNS dilates the pupil is almost fully mediated by the VNS-evoked recruitment of the cholinergic system.pic.twitter.com/JzEZyZEoEq
Prikaži ovu nit -
We conclude that pupil dilation is a sensitive biomarker for the moment-by-moment titratable effects of VNS on brain state.
Prikaži ovu nit -
We hope our results will be helpful for expanding the use of VNS in health and disease, particularly for settings that require closed-loop control of brain state in real time.
Prikaži ovu nit -
PS: shout-out to
@marius10p,@computingnature (#Suite2P) and@DeepLabCut for developing these amazing open source analysis tools.Prikaži ovu nit
Kraj razgovora
Novi razgovor -
Čini se da učitavanje traje već neko vrijeme.
Twitter je možda preopterećen ili ima kratkotrajnih poteškoća u radu. Pokušajte ponovno ili potražite dodatne informacije u odjeljku Status Twittera.