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PS: shout-out to
@marius10p,@computingnature (#Suite2P) and@DeepLabCut for developing these amazing open source analysis tools.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
We hope our results will be helpful for expanding the use of VNS in health and disease, particularly for settings that require closed-loop control of brain state in real time.
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We conclude that pupil dilation is a sensitive biomarker for the moment-by-moment titratable effects of VNS on brain state.
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Path analysis indicated that the extent to which VNS dilates the pupil is almost fully mediated by the VNS-evoked recruitment of the cholinergic system.pic.twitter.com/JzEZyZEoEq
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Further, parametrically varying VNS resulted in titratable release of acetylcholine in cortex.pic.twitter.com/NnVPOluvek
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We developed an approach to VNS in head-fixed mice on a treadmill, and use it to show that pupil dilation parametrically scales with the electrical parameters of stimulation.pic.twitter.com/WN4s4DWDmY
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Despite the wide and growing use of VNS, the mechanisms underlying its clinical benefits are still largely unknown, and there is a lack of biosensors for assaying stimulation efficacy in real time.
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New paper by the
@McGinleyLab,@jwdegee and others: "Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve." https://www.biorxiv.org/content/10.1101/2019.12.28.890111v1 …pic.twitter.com/9Z4YRmGCrB
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Interested in graded control of pupil dilation (
@DeepLabCut) and cortical neuromodulation using selective and parametric stimulation of the mouse vagus nerve? Come check out our poster U4 at this afternoon at#SfN! https://www.abstractsonline.com/pp8/#!/7883/presentation/68307 … With@jwdegee,@bcm_neuroscipic.twitter.com/llW2bT6WvJ
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McGinley-lab proslijedio/la je Tweet
Interested in the behavioral correlates of phasic arousal across species and domains of decision-making? Come check out our poster BB84 this afternoon at
#SfN19! https://www.abstractsonline.com/pp8/#!/7883/presentation/51557 … With@donner_lab,@McGinleyLab,@k_tsetsos,@AnneEUrai,@bcm_neurosci.pic.twitter.com/3005yNW8zt
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Want to study the neural circuits underlying brain states and adaptive decision-making using cutting-edge physiological tools in behaving mice? I am recruiting for multiple experimental and computational postdoc positions (https://www.bcm.edu/research/labs/matthew-mcginley/ …). Let’s talk in person at
#SfN19!pic.twitter.com/2QWnQ2IO32
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A general principle: phasic arousal optimizes decision computations in mice and humans. Results of a fruitful collaboration with the overseas
@donner_lab, featuring@jwdegee@k_tsetsos and @neuroscidoc. Stay tuned for more! https://www.biorxiv.org/content/early/2018/10/19/447656 …pic.twitter.com/ZOcaCq0hUU
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