George A. Mashour, MD, PhD

@MashourGeorge

Anesthesiologist, Neuroscientist, and Translational Scientist at the University of Michigan

Vrijeme pridruživanja: listopad 2019.

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  1. I am proud to be a founder & executive sponsor of U-M's new Center for Drug Repurposing. Our library of >5000 clinically tested drugs is already yielding exciting discoveries. With >7000 diseases that have no therapy, we need more efficient drug discovery.

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  2. proslijedio/la je Tweet
    31. sij

    Listen as of and I discuss Michigan OPEN as an approach to help health practitioners manage patient pain in routine procedures satisfactorily, with fewer medications. Addressing the opioid crisis: ending over-prescription

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    29. sij

    An important paper indicating that populations of prefrontal neurons encode the contents of consciousness even in the absence of any requirement for report -- in good agreement with Global Neuronal Workspace theory.

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    25. sij

    On this month's our host sits with guest Co-Director of Michigan Opioid Prescribing Engaging Network to discuss how his organization aims to apply a preventative approach to the opioid epidemic. Airs Tuesday, January 28 at 7 p.m. on

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    22. sij

    Very welcome editorial from ⁦⁩ - prioritising robust reproducible results over convenient narratives. An important contribution to the sea change.

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  6. Great magazine piece on pain that features investigators from the Chronic Pain & Fatigue Research Center, part of U-M Anesthesiology. Our multidisciplinary team continues to expand knowledge of nociplastic network changes that create pain in the brain.

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  7. Decoding oblivion: pharmacologically induced states of unconsciousness help machine learning models classify pathological states of unconsciousness. Congratulations to investigators in the U-M Center for Consciousness Science/Department of Anesthesiology!

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  8. The U-M Center for Consciousness Science hosted a symposium on psychedelic neuroscience in late 2019- the speakers were interviewed by comedian and academic enthusiast Shane Mauss. The podcasts are now available! To hear more, tune in (but don't drop out):

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    13. sij

    Read about the three blind mice and a tail of discordant trials. Can we make sense of conflicting evidence?

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    Altered Oscillations: The Modulatory Effect of DMT on Brain Waves: A recent Nature paper provides novel insights into the neural correlates of the Breakthrough Experience associated with DMT.

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  11. Renowned UM neuroscientist Huda Akil reveals the secret to sartorial splendor in your Specific Aims page. Don't let the study section members be the ones to dress you down!

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    10. sij

    I am very grateful to my wonderful cochair for the two summits, Dr. Chad Brummett . Here's our Op-Ed: Treating Stigma to Prevent Opioid Overdose Deaths. Thx also to all at , the Boston summit advisors, those I consulted,

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  13. Does the EEG truly reflect consciousness? Dinesh Pal, Duan Li, and Ph.D. students from UM Anesthesiology's Center for Consciousness Science dissociate levels of consciousness and EEG measures in a provocative Journal of Neuroscience article (in press):

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    7. sij

    . neuroscientists found that a region in the thalamus of rats regulates a circuit linked to the prelimbic cortex, a brain region that governs certain urges linked to addiction. This pathway may one day become a new therapeutic target.

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  15. Congratulations to Boris Heifets, from Stanford, for his innovative work recently published in Science Translational Medicine! This is a fantastic example of an anesthesiologist advancing the frontiers of neuroscience as well as psychedelic research with translational potential.

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  16. Found in translation? In research, the translational process turns scientific discoveries into improved health. But how can we predict how "translatable" fundamental science is? The recent work of Hutchins and colleagues is an important step forward:

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    5. sij

    Scientists Uncover ‘Strong Relationship’ Between Psychedelic Use And Connection With Nature -

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  18. Pain in the brain: neuroscientist Chelsea Kaplan, new faculty member in U-M anesthesiology, is taking a network science approach to understanding and treating chronic pain. See her 2020 and 2019 cover articles in PAIN: &

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  19. As you reflected on anesthetizing plants or paramecia, you might have asked yourself: "How low can we go?" U-M anesthesiology paired up with quantum chemists to find out. See the effects of modern anesthetic ethers on entangled photons in this 2019 study:

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    4. sij

    It is truly practical to teach clinicians to recognize typical EEG features associated with general anesthesia and wakefulness. We must cease our over-reliance on over-simplistic proprietary indices.

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