"T cell responses may be more sensitive indicators of SARS-Co-V-2 exposure than antibodies. ... data relying only on the detection of SARS-CoV-2 antibodies may lead to a substantial underestimation of prior exposure to the virus" @FafiKremer https://www.medrxiv.org/content/10.1101/2020.06.21.20132449v1 …
Yes. Helps explain the rapid spread of the disease under the radar, as well as the age differentials in e.g. Spain, where antibody prevalence increases by age in a manner that is hard to explain by differences in exposure.
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Is antibody creation influenced by age? Or how does it explain the Spanish data? I don’t understand how it facilitates spread under the radar either. (This is not my field...)
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Maybe, or, a younger people have a different type of immune response, or, innate immunity is more common in younger people. There is a lot we do not know, but since higher exposure is an unlikely explanation, it is clear that antibodies do not tell the whole story.
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