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MarkHoofnagle's profile
Mark Hoofnagle
Mark Hoofnagle
Mark Hoofnagle
@MarkHoofnagle

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Mark Hoofnagle

@MarkHoofnagle

Trauma/Critical Care/Acute Care Surgeon. MD/PhD. FACS. UVa/UMD/UPenn. Asst Professor of Surgery at Wash U. Blocking is curating.

St Louis, MO
surgery.wustl.edu/people/mark-ho…
Joined March 2012

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    1. David Gorski, MD, PhD‏Verified account @gorskon 7 Oct 2020

      David Gorski, MD, PhD Retweeted  🇺🇸36 Chambers 🇺🇸

      I'm a cancer surgeon at Wayne State and Karmanos. I've never worked for Henry Ford in my entire career, Einstein.https://twitter.com/Chamb3r5/status/1313766982005686273 …

      David Gorski, MD, PhD added,

       🇺🇸36 Chambers 🇺🇸 @Chamb3r5
      Doctors take oaths to help us. This Dr. Is a outright liar. My own personal doc. Who is also a ER surgeon for Henry Ford (who did the study on H) has treated countless patients w #Hydroxychloroquine. Want proof it works? Look at Uganda. Let me remind you doc, you took an oath! https://twitter.com/gorskon/status/1313693630113222656 …
      18 replies 5 retweets 130 likes
    2. Mark Hoofnagle‏ @MarkHoofnagle 7 Oct 2020
      Replying to @gorskon

      Can't wait until they figure out the grand orange idiot was not given HCQ when he got sick.

      1 reply 0 retweets 33 likes
    3. David Gorski, MD, PhD‏Verified account @gorskon 7 Oct 2020
      Replying to @MarkHoofnagle

      I know the "demon sperm" doctor is very unhappy that Trump isn't getting HCQ. 😂

      3 replies 0 retweets 24 likes
    4. Mark Hoofnagle‏ @MarkHoofnagle 7 Oct 2020
      Replying to @gorskon

      Right? Turns out, when you have the best medicine available to you, HCQ gets shit-canned and you end up on dex/remd and now mAb. Not that I think the evidence for any of those is better than half-baked bullshit. Even the metaanalysis on dex is overweighted by a single trial.

      1 reply 3 retweets 29 likes
    5. Mark Hoofnagle‏ @MarkHoofnagle 7 Oct 2020
      Replying to @MarkHoofnagle @gorskon

      And because of the well-known shenanigans around remdesivir we will *never* know if it works, and I suspect it doesn't. It should probably be given as prophylaxis, and I think it is worthless in severe disease.

      2 replies 5 retweets 16 likes
    6. David Young‏ @davideyoungmd 7 Oct 2020
      Replying to @MarkHoofnagle @gorskon

      Remdesivir was shown to help in a very carefully conducted randomized, placebo controlled, large study. It is not a miracle drug and no one expected that. But the pivotal study, published in the NEJM was solid.

      1 reply 0 retweets 2 likes
      Mark Hoofnagle‏ @MarkHoofnagle 7 Oct 2020
      Replying to @davideyoungmd @gorskon

      No, it wasnt. They changed the endpoints midway through from the one we cared about to one we didnt. I read the study, and its a goddamn travesty. I now prescribe this drug as a default, and we will *never* know if it impacts mortality in the way we prescribe it.

      9:10 AM - 7 Oct 2020
      • 17 Likes
      • An Otherwise Blameless Life Dr. Chim Richalds Rachael Batten ☘️ Laura ✊🏽 Dr. mem_somerville | Wossamotta U Carolyn Parsons 🇦🇴🇵🇹🇺🇸🏳️‍🌈🖌🐄🔬 the fool 🃏 Sophie Rapp elkemt
      2 replies 0 retweets 17 likes
        1. New conversation
        2. Mark Hoofnagle‏ @MarkHoofnagle 7 Oct 2020
          Replying to @MarkHoofnagle @davideyoungmd @gorskon

          I’m still furious about it. We could have had an answer but we were too impatient to await a firm result. And they changed the endpoints, very suspiciously, to the endpoint that was significant in the abbreviated trials from China. So much shenanigans.

          1 reply 1 retweet 16 likes
        3. Mark Hoofnagle‏ @MarkHoofnagle 7 Oct 2020
          Replying to @MarkHoofnagle @davideyoungmd @gorskon

          One of the great harms we will see, looking back on this year, was the iterative destruction of FDA safeguards and safety on evidence for EUAs, driven by politics. And, as much as I like Fauci, he failed to object to major shenanigans on a trial being overseen by NIAID.

          1 reply 2 retweets 23 likes
        4. Show replies
        1. New conversation
        2. Nathan Favero‏ @favero_nate 7 Oct 2020
          Replying to @MarkHoofnagle @davideyoungmd @gorskon

          I read the study too, but result was significant on both the original and the new endpoint, right? So the midpoint change didn't actually affect the result. The pure mortality rate difference was not quite significant, but I don't think that was ever the endpoint?

          2 replies 0 retweets 0 likes
        3. Nathan Favero‏ @favero_nate 7 Oct 2020
          Replying to @favero_nate @MarkHoofnagle and

          * endpoint change

          0 replies 0 retweets 0 likes
        4. End of conversation

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