2/ When we started this project years ago, we thought the ventral hippocampus (vH) would be primarily involved in linking space and reward via its connections with the nucleus accumbens (NAc).
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3/ Surprisingly, it’s not. At least not in this type of spatial task. Only dorsal hippocampus (dH) recruits spatial-reward representations in the NAc. Here’s how we found that out.
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4/ We used chronic tetrode recordings in all 3 regions and detected hippocampal sharp-wave ripples--bursts of memory reactivation across brain structures--to ask how dorsal and ventral hippocampus recruit neurons in the NAc.
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5/ First, we found that dH and vH ripples are out-of-sync with each other, indicating that they talk to the NAc at different times.
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6/ These out-of-sync ripples modulate NAc neurons in opposite ways, with neurons activated by dH ripples typically suppressed by vH ripples, and vice-versa. Weird!
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7/ Turns out, dH-activated NAc neurons have different representations during the task than vH-activated neurons. So these different representations are ‘reactivated’ separately during dH and vH ripples.
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8/ Only the dH-activated neurons encode relative position on spatial paths and past reward outcomes. And the vH-activated neurons encode... nothing useful in this task. (believe me, I was disappointed too!)
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9/ So there it is! I’m extremely grateful to my advisor Loren, my teammate Hannah, the whole Frank Lab, and everyone who provided feedback on this project over the years. Couldn’t have done it without you!
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Amazing paper on dorso/ventral hippocampus- accumbens interactions during learning. One of my favorites posters last SfN
Many congrats @MariRSosa !! -
Thanks so much
@antferrui! Can’t wait to see where your dorsal/ventral work leads! - Još 2 druga odgovora
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