David Margolis

@MargolisLab

Neuroscience lab interested in imaging neural circuit activity in mice

Rutgers, New Brunswick
Vrijeme pridruživanja: svibanj 2013.
Rođen/a 01. travnja

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  1. Prikvačeni tweet
    11. tra 2019.

    Our paper is out in !! we find distinct synaptic and behavioral effects of stimulating S1 or M1 inputs to dorsal striatum, with striatal PV interneurons playing an important role

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  2. 4. velj

    Buzsaki is bigger than astrocytes or cerebellum 😂

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  3. proslijedio/la je Tweet
    30. sij

    👉New research from our team shows that local and dynamic D2- to D1-neuron modulation in the striatum is necessary for reshaping goal-directed learning. Find out more in our study published today!

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  4. proslijedio/la je Tweet
    26. sij

    The dendritic spatial code: branch-specific place tuning and its experience-dependent decoupling

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  5. proslijedio/la je Tweet
    20. sij

    Thrilled to share our paper out today in Nature Neuroscience. We developed a novel chemogenetic strategy (ciPSI) to block new protein synthesis in specific cell types using an engineered drug-inducible version of eIF2α kinase PKR. 1/n

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  6. proslijedio/la je Tweet
    23. sij

    1/8 Excited to announce that our paper is out in eLife: Thank you and for the hard work! Special thanks to eLife for their amazing editorial process. Wish all journals would adopt similar policies.

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  7. proslijedio/la je Tweet
    23. sij

    A computational model showed that even if all the cells were almost identical, strong cholinergic activation of all neurons would drive a winner-takes-all symmetry breaking, where just a few neurons spike quickly, and suppress their neighbors.

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  8. 24. sij
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  9. proslijedio/la je Tweet
    21. sij

    Modulation of Coordinated Activity across Cortical Layers by Plasticity of Inhibitory Synapses

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  10. 21. sij
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  11. proslijedio/la je Tweet

    With , we've designed easy-to-build rigs that you can put together from off-the-shelf, open-source parts and some 3D printed components. At , we built it in 1 day! Parts list and instructions: 7/10

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  12. proslijedio/la je Tweet

    After >2 years of effort by our team in 7 labs, we present to you: 3 million choices from 101 mice in a standardized decision-making task. 🐭 "A standardized and reproducible method to measure decision-making in mice" Story time! 🧵👇 1/10

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  13. 17. sij
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  14. proslijedio/la je Tweet
    17. sij

    Nobel prize-winning neuroscientist Lord Adrian was not at all terrifying.

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  15. proslijedio/la je Tweet
    17. sij

    Cool work from Masminidis lab showing importance of DA for generating movements via impact on SR associations

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  16. proslijedio/la je Tweet
    15. sij

    Wondering how cortical signal flow depends on the task your doing and on your strategy in individual trials? Check out our new preprint at . Many thanks to Yasir Gallero-Salas, , and all co-authors.

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  17. proslijedio/la je Tweet
    14. sij

    Patterns appear to move.

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  18. proslijedio/la je Tweet
    14. sij

    Mendes-Gomes et al. 2020 win the award for most realistic threat paradigm. "The threat stimulus was a wild rattler snake (Crotalis durissus terrificus), a species native to Brazil, weighing approximately 1.6 kg."

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  19. proslijedio/la je Tweet
    14. sij

    I’m so excited for this issue of Current Opinion in Neuro: it’s all about behavior! So many amazing contributors: , , , Matt Diamond, , Robert Froemke, Gilles Laurent, , Dora Angelaki

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  20. proslijedio/la je Tweet
    14. sij

    I can watch these little guys firing for hours. Actually that's what I do for a living really...

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  21. proslijedio/la je Tweet
    12. sij

    The corticospinal tract (CST) may initially have served a sensory function, as lumbar-projecting CST neurons do not encode movement but rather sensory gating (in mice). Not sure exactly why sensory would precede motor, but for sure CST ≠ motor there.

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