Molecular Cancer Research

@MCR_AACR

MCR publishes rigorous, timely, and impactful studies that define the molecular basis of human cancers. Editor-in-chief: Published by

Vrijeme pridruživanja: srpanj 2018.

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  1. Prikvačeni tweet
    14. sij
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  2. Lysine Specific Demethylase 1 (LSD1) promotes epithelial-mesenchymal transition via AKT in with a mutation in the catalytic subunit of . Paper by Miller et al

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  4. Liu et al find Ubiquitin-conjugating enzyme E2C (UBE2C) elevated in patients with and upregulation to be associated with patient poor outcome. Read more about the molecular mechanisms involved here:

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  5. proslijedio/la je Tweet
    prije 7 sati

    Check out👇🏼 our new combo targeting regulator G9a and Chk1 to cause replication 🧬 catastrophe in !!! in ⁦⁩ ⁦

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  6. 31. sij

    Combined inhibition of Src and improves overall survival in mouse model of by targeting signaling and remodelling , Dosch et al report.

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  7. 31. sij

    Stangl et al show that all fusions convey resistance to targeted against the receptor family but fusion partners influence the effects.

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  8. 28. sij

    Targeting has significant therapeutic effects: it reduces and sensitizes malignant cell death in T cell cell lines Eroglu et al. report here:

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  9. 28. sij

    (CA) in cancer disrupts and sensitizes cells to autophagy inhibition. Denu et al suggest CA as for treatment with autophagy inhibitors.

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  10. proslijedio/la je Tweet
    24. sij

    Proud to share our recent study : O-GlcNAc transferase regulates cancer stem-like potential of breast cancer cells Congrats to first author Neha and co-authors Giang, Lorela , Ayonika, Zach, Dimpi and Val!

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  11. 24. sij

    Can colorectal be reverted into normal-like cells? Lee et al find that depletion of histone methyltransferase reactivates colon-specific genes and supresses associated genes.

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  12. proslijedio/la je Tweet
    24. sij

    Antibody–Drug Conjugates: A Comprehensive Review (27 pages of references) Selection of antibody moiety, Linkers, Cytotoxic payloads or warheads, MoA of ADCs, Resistance, Optimization strategies, ADCs in clinical dev, Conclusions & perspectives

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  13. proslijedio/la je Tweet
    24. sij

    Excited to share my manuscript reporting the dependency of breast cancer stem-like cell characteristics on OGT (an intracellular sugar post-trans mod) and proteins that may facilitate this. thank you to my colleagues and advisor

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  14. 23. sij

    PRMT6/ILF2/MIF signaling axis plays a unique role in promoting . Avasarala et al discuss new therapeutic opportunities by developing inhibitors of and ILF2 heterodimerization.

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  15. 22. sij

    Nguyen et al propose higher reactive oxygen species levels plus increased KYN/TRP ratio as relevant biomarker to select patients for future treatment with inhibitors

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  16. 22. sij

    Zhang et al show that deregulated RNA binding protein Argonaute 2 acts as a MYC transcript stabilizer to promote hepatocellular carcinomas independent of miRNAs.

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  17. 21. sij

    Combined inhibition of Src and improves overall survival in mouse model of by targeting signaling and remodelling , Dosch et al report .

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  18. proslijedio/la je Tweet

    Interesting new work in HCC with contribution from two and in Xin Wei Wang’s lab in the Laboratory of Human Carcinogenesis at the

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  19. proslijedio/la je Tweet
    15. sij

    My first paper in grad school! We report a dependency of some highly aggressive, metastatic breast cancer cells on mitochondrial serine and one-carbon unit metabolism. Available online at

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  20. 13. sij

    Targeting has significant therapeutic effects: it reduces and sensitizes malignant cell death in T cell cell lines Eroglu et al. report here:

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