In this commentary we outline the need to consider the implications of simple integration of #SABV versus the need for specialisation of sex differences research and the need for research on female-specific and male-specific factors as they relate to health research.pic.twitter.com/h1Oj1mS5sS
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It is clear that sex differences research is needed but that the simple integration of
#SABV may not go far enough to really propel the field forward without attention to implementation issues.Prikaži ovu nit -
A major implementation issue is analysing the data by sex, & another is using appropriate sample sizes for detection of sex differences.
@arianneyka does some simulations to show that greater sample sizes are needed if the effect size is 50-75% of the effect in the opposite sexpic.twitter.com/TcEaTQmB3APrikaži ovu nit -
We highlight that hormonal cycles are variable in males as well as females. Past data (PMID: 24456941) indicate that although female mice data is not more variable than male mice data, that housing in males leads to variability which could ultimately be due to hormone levelspic.twitter.com/mFFXpI1fKM
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And although not mentioned in our commentary, check out this cool paper by Smarr, Grant Prendergast, Zucker, Kriegsfeld https://bsd.biomedcentral.com/articles/10.1186/s13293-016-0125-3 … showing that females have greater infraradian variability whereas males show greater ultraradian variability
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We highlight that proper incorporation of
#SABV will improve outcomes for women & men. Inattention to#SABV can be catastrophic for drugs appropriate for men with the ex of 'lazaroids' - what other discoveries have we missed because of lack of analysis by sexpic.twitter.com/HRMPQBBUNRPrikaži ovu nit -
We outline data indicating the lack of studies in females https://www.eneuro.org/content/4/6/ENEURO.0278-17.2017 … and the need for the research community to endorse the importance of
#SGBA or#SABV because it's just good sciencepic.twitter.com/Ok3Xh9pDxfPrikaži ovu nit
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