See: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420028/ … and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1564166/ … and https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30317-2/fulltext … and https://www.nejm.org/doi/full/10.1056/NEJM200305153482017 … and https://www.nature.com/articles/s41375-020-0848-3 … and https://watermark.silverchair.com/39-8-1247.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAoswggKHBgkqhkiG9w0BBwagggJ4MIICdAIBADCCAm0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMEsUn0zjzpoX-qwkNAgEQgIICPoAr73-Tspk7LYXbCHXz5wpF6hnAizVR3zlo-7E6ReYwe3F-t8EAswd6QUx6F0eoRhCBIYFH8pVmZRaMX1C-YZFrjTOCkjByFPT79r9sURjs3XAGDexqWMpCnesdrQpOaVeLnzE2eZcy1oSkgogxE6xOfStOX9F9XWI6UAK_75ABnXNQTa3qbKIFUzuEuFV-Z0YlD4SHe9QezYDTFQRNwnAMoNcLJZE3zyX2oyjpyibFNi3LW_Bu-7sQw0XxnJIlm6Xka-s67oRCHswJSZmCMl8u7rEsNd-HkW9Vld9NOrDjzs82A9_-CajkZDUVidJbT2bzgOU4EC2P7-Lp3PqYxPDr1wOjlrKF7jmixWjrlESMatCzj-PXi7Xjh5OuirHI0LrYzDtH4pTj6lS4HDO8I401p4jBvGBYPUNKsYPIK32rFjIldnh61gELzS53hQos28BKuJ6SRRdTmy9olH78vMR-WnfMWV3M0gdCsrMvScQkWACJDD-gSOL1jCPWrWbuxFVuIwXWSxFiuTc_FeJriIH7MeBnbNF0LIdHR9PgIZQ9Csyq5nFLxrF7JlPQqWkmOayzEDtkpeUDfwRUHURD1-Nmi9onBmpOi0FqS15CfP-WgNvD2FSo7wulHKF7za0U74xFCZml1JkQGmXt5OO9hh9-qS-ieRVrwKbWBvKEuc17S__yZ5wz_ZBlWrUQabL73NjokvqLYec8TrCdnszO3wxfgIgnL6GaA7lqi3gR1gDxd_kOVWhXBycFMcIBgGE … and https://www.scmp.com/article/466557/authority-restricts-steroid-use-treating-sars … https://www.telegraph.co.uk/news/worldnews/asia/hongkong/1431693/Sars-patients-suffer-brain-damage-from-steroid-cocktail.html … and https://www.voanews.com/archive/some-recovering-sars-patients-treated-medication-side-effects …
Loads of excitement today about use of steroid dexamethasone to treat #COVID19 . Steroid use for #SARS 2003/4 had long lasting side effects & was controversial. I want to caution, not dismiss use for COVID. A few references worth studying now.
MOREhttps://twitter.com/Nature/status/1272904516535541764 …
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Doses & specific drugs used in steroid treatment of
#SARS in 2003/4 compared to dexamethasone use for#COVID19 but let's consider side effects issues. More citations: https://europepmc.org/articles/pmc7079838/bin/198_2016_3824_moesm1_esm.docx … and https://wwwnc.cdc.gov/eid/article/9/9/03-0362_article … and http://sarsreference.com/sarsref/treat.htm … andhttps://www.straitstimes.com/singapore/bone-woes-hit-survivors-due-to-steroid-treatment …Show this thread
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See the “MATH” protocol
@Covid19Critical or https://covid19criticalcare.com . With supporting research.Thanks. Twitter will use this to make your timeline better. UndoUndo
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and you have to wonder what the steroid does to an underlying condition, which a lot of people have who end in in ICU. a steroid for an t1 diabetic is catastrophic.
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Remember when poorly designed chloroquine studies with inadequate data were published prematurely?
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The difference here is that the president has no financial stake, so no obsessive need to flog it to make himself money.
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Hate when these studies become public. Dex is a potent drug that while leading to increased survival could lead to a whole host of undesirable deleterious side effects. Survival at what cost?
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How does this effect autoimmune population, specifically Multiple Sclerosis?
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Thank you for this tweet. This was a concern i had, when I first heard of the use a couple weeks ago when a pt i knew was receiving the drug. He OK, but I was concerned especially as he was elderly..
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Be interesting to see if it also impacts stroke frequency at all, or if this all boils down to ameliorating the cytokines storm.
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