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  1. Pinned Tweet
    10 Sep 2019

    Excited to announce AGE1 Batch 3 Applications are open! Build your biotech co with $500K + 3 mo in SF, submissions close Dec 7.

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  2. Feb 1

    What is the best evidence for natural selection as the major driver of evolution? Trying to understand the modern synthesis w/o getting stuck in semantics.

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  3. Jan 29

    Friend gave me Ride of a Lifetime, fun read. Ike Perlmutter (Marvel CEO) is great. No public interviews or headshots. Greets Bob Iger (Disney CEO) in an acquisition discussion with a glass of water and banana from Costco.

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  4. Jan 28

    Looking for great ML engineers who want to work in longevity - DM/email (ldeming.www@gmail.com) if interested!

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  5. Jan 27

    notes Her2 is the obvious example here.

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  6. Jan 27

    Have any target discovery/validation biotechs successfully taken a drug to market based on an internally discovered target? Current baseline for this is 'no', but I'm sure one must exist.

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  7. Jan 27

    Millenium, year 1 - $8M in revenue. I think Genentech was in the black <2 yrs from starting. Curious what founding year revenue looks like for the most successful companies in bio.

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  8. Jan 24

    Compiling advice for ambitious, science-oriented teenagers - would anyone (ideally target audience!) have time to review? DM/email ldeming.www@gmail.com if so!

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  9. Jan 15

    6/n Anyway, where am I wrong?

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  10. Jan 15

    5/n Related to an issue I don’t understand in stat physics where people talk about the full state space but not trajectories that could just be totally inaccessible given some starting point

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  11. Jan 15

    4/n Seems like theorizing about a type of evolution that only selected for broken organisms - just not going to happen pragmatically

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  12. Jan 15

    3/n Leaving aside how you define happiness, isn’t this just illogical (like, philosophy is considering situations the laws of human nature don’t allow us to explore)?

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  13. Jan 15

    2/n The central argument (afaik) is that, comparing two populations, more people w/ on average less happiness is better as long as the sum of happiness over everyone is larger

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  14. Jan 15

    1/n I’m confused by Derek Parfit’s ‘Repugnant Conclusion’. Can anyone help me understand the right way to think about this?

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  15. Jan 13

    Go ! Congrats on the partnership w/ Novo Nordisk.

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  16. Jan 12

    I'm extremely confused re how to think about 'levels of selection' in evolution. If anyone can explain this clearly or has good links please lmk, would be insanely grateful! Looking for explanations that mathematician-types would be aesthetically satisfied w/.

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  17. Jan 8

    "Being self-funded, he did not depend on established institutions – he owned an institution." - on Auguste Lumiere. Retirement goals!

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  18. Jan 6

    We're hiring for a Principal investing role at Longevity Fund - applicants from a diverse set of backgrounds are welcome.

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  19. Retweeted
    Jan 5

    Consider: millions of years ago our antecedents gave a massive sacrifice of their left hemisphere. We lost a tremendous amount of short term memory and replaced it with Broca’s, Wernicke & the phonological loop. But why? So we can—talk. Thus chimpanzees can do this—we can’t:

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  20. 29 Dec 2019

    For those who have never experienced it, Paprika by Satoshi Kon is (imho) one of the most beautiful and intricate animated films ever. Spirited Away for adults. A smarter Inception. Note very weird so prob don't watch w/ kids. So sad Kon died before making Dreaming Machine.

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  21. 27 Dec 2019

    'I like you and your papers...equally!' Great love letter material.

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