body { -ms-overflow-style: scrollbar; overflow-y: scroll; overscroll-behavior-y: none; } .errorContainer { background-color: #FFF; color: #0F1419; max-width: 600px; margin: 0 auto; padding: 10%; font-family: Helvetica, sans-serif; font-size: 16px; } .errorButton { margin: 3em 0; } .errorButton a { background: #1DA1F2; border-radius: 2.5em; color: white; padding: 1em 2em; text-decoration: none; } .errorButton a:hover, .errorButton a:focus { background: rgb(26, 145, 218); } .errorFooter { color: #657786; font-size: 80%; line-height: 1.5; padding: 1em 0; } .errorFooter a, .errorFooter a:visited { color: #657786; text-decoration: none; padding-right: 1em; } .errorFooter a:hover, .errorFooter a:active { text-decoration: underline; } #placeholder, #react-root { display: none !important; } body { background-color: #FFF !important; }

JavaScript is not available.

We’ve detected that JavaScript is disabled in this browser. Please enable JavaScript or switch to a supported browser to continue using twitter.com. You can see a list of supported browsers in our Help Center.

Terms of Service Privacy Policy Cookie Policy Imprint Ads info © 2022 Twitter, Inc.

Follow

LabScribbles

@LabScribbles

Open access Huntington's disease research by Dr Rachel Harding, she/her, SGC Toronto, zenodo.org/communities/la…

Toronto, Ontariolabscribbles.comJoined December 2015

LabScribbles’s Tweets

Pinned Tweet

Our latest preprint is now available on bioRxiv! We describe #opensource resources, validated by biophysical methods & cryoEM for investigating huntingtin structure-function. Thanks everyone for their hard work on this collaborative project! #openscience biorxiv.org/content/10.110

Susan Lea and 5 others

1

11

13

LabScribbles Retweeted

Our preprint describing how HTT binds poly ADP ribose, and how PAR signaling is dysregulated in HD patient CSF and cells, is up! Many thanks to our big group of international collaborators and to

for funding this project biorxiv.org/content/10.110

Embedded video

0:10

260 views

4

7

19

LabScribbles Retweeted

Hilal Lashuel-هلال الأشول (Private Account)

Just Published/The Scientist. In this opinion piece I share my thoughts on the new

publishing model and what is needed to change the publishing system All of us must commit to taking the risks needed to change how research is shared and evaluated

the-scientist.com

Opinion: In Publishing, Don’t Make the Perfect the Enemy of the Good

All members of the scientific community must commit to taking the risks needed to change how research is shared and evaluated.

4

44

76

Show this thread

Congratulations

@CherylArrowsmi1

on this well deserved award!

Quote Tweet

We are excited to announce the recipient of the 2022 NAVIGATOR Research Program, Prof. Cheryl Arrowsmith from the University of Toronto. For more information on the NAVIGATOR Research Program and past recipients, visit huntingtonsociety.ca/navigator-prog

2

8

LabScribbles Retweeted

We are excited to announce the recipient of the 2022 NAVIGATOR Research Program, Prof. Cheryl Arrowsmith from the University of Toronto. For more information on the NAVIGATOR Research Program and past recipients, visit huntingtonsociety.ca/navigator-prog

1

6

15

LabScribbles Retweeted

I talked with

and Dr. Rachel Harding of

about the research presented at this year's HDSA Convention in Atlanta. As always, it was a pleasure talking with them - so much fun! Take a listen!

blogtalkradio.com

HDBuzz Roundtable #1

For more information about HDBuzz, please visit their website or twitter.

9

11

LabScribbles Retweeted

Jeff Carroll, PhD

We're still trying to hire an experienced research scientist to help with very exciting mouse ASO studies in HD. Bellingham is awesome, the salary is good, and the people are cool! If you know anyone with good mouse skills, send them our way! hr.wwu.edu/careers-staff?

1

23

25

Show this thread

LabScribbles Retweeted

Cheryl Arrowsmith

@CherylArrowsmi1

Please RT. This is a wonderful opportunity to work with the amazing Rachel Harding

who leads our #Huntingtonsdisease program. Join us to help tackle this terrible disease.

@PMResearch_UHN

Quote Tweet

Structural Genomics Consortium (SGC)

The SGC Laboratory at U of T is seeking a Postdoctoral fellow to join our Huntington’s disease research team. Do you have Ph.D. degree in biochemistry, biophysics, structural biology or related field? For more details visit bit.ly/3u25774 #Structuralbiology #hiringnow

2

15

12

LabScribbles Retweeted

Structural Genomics Consortium (SGC)

The SGC Laboratory at U of T is seeking a Postdoctoral fellow to join our Huntington’s disease research team. Do you have Ph.D. degree in biochemistry, biophysics, structural biology or related field? For more details visit bit.ly/3u25774 #Structuralbiology #hiringnow

NEW! Postdoctoral Fellow, University of Toronto

The Structural Genomics Consortium (SGC) is an international public-private partnership that supports the discovery of new medicines through open science research (www.TheSGC.org). The SGC Laboratory...

10

8

LabScribbles Retweeted

Come share a lab bench with me in Toronto! Fun group doing exciting research on Huntington's disease, with a focus on structural biology/biochemistry and proteomics. Please like/share/RT/ping/poke/whatever the kids do these days #postdocjobs #chemtwitter #AcademicTwitter

Quote Tweet

Structural Genomics Consortium (SGC)

The SGC Laboratory at U of T is seeking a Postdoctoral fellow to join our Huntington’s disease research team. Do you have Ph.D. degree in biochemistry, biophysics, structural biology or related field? For more details visit bit.ly/3u25774 #Structuralbiology #hiringnow

6

7

LabScribbles Retweeted

Branaplam was originally designed to treat spinal muscular atrophy, but a new paper outlines how it could hold promise for treating Huntington’s. This oral drug lowers huntingtin protein and will now be tested in a study called VIBRANT-HD.

A spoonful of branaplam helps the huntingtin go down

Branaplam was originally designed to treat spinal muscular atrophy, but a new paper outlines how it could hold promise for treating Huntington’s. This oral drug lowers huntingtin protein and will now...

2

29

58

LabScribbles Retweeted

Structural Genomics Consortium (SGC)

The SGC Laboratory at U of T is seeking a Postdoctoral fellow to join our Huntington’s disease research team. Do you have Ph.D. degree in biochemistry, biophysics, structural biology or related field? For more details visit bit.ly/3u25774 #Structuralbiology #hiringnow

9

8

LabScribbles Retweeted

Cheryl Arrowsmith

@CherylArrowsmi1

SGC-Toronto is looking for a Sr Research Assoc (PhD), & postdocs in structural biology, protein science & biophysics, comp chem related to antiviral drug discovery, #HuntingtonsDisease, cancer. Keep your eyes on thesgc.org/careers

1

19

32

LabScribbles Retweeted

Cheryl Arrowsmith

@CherylArrowsmi1

Wonderful to attend first in-person conf in 2 yrs at last week’s #Huntingtonsdisease therapeutics meeting along with

,

, & Caroline Benn

here sporting our #RosalindFranklin dresses from

@ShenovaFashion

for #womeninSTEM

3

3

39

LabScribbles Retweeted

Check out research updates from Day 1 of the 2022 HD Therapeutics Conference #HDTC2022

Huntington’s disease therapeutics conference 2022 - Day 1

Check out research updates from Day 1 of the 2022 HD Therapeutics Conference #HDTC2022

17

23

LabScribbles Retweeted

From next Tuesday 1st March, we will be live-tweeting three days of updates from the CHDI Foundation Therapeutics Conference in Palm Springs CA. This will be the first major in-person #HuntingtonsDisease scientific conference in 2 years.

1

24

50

Show this thread

LabScribbles Retweeted

A new imaging tool means that scientists can now directly measure the levels of the toxic huntingtin protein in animal models of Huntington’s disease, letting us see how well huntingtin lowering therapies are working in their brains

Shining a spotlight on huntingtin: a tool to measure huntingtin-lowering in real time

A new imaging tool means that scientists can now directly measure the levels of the toxic huntingtin protein in animal models of Huntington’s disease, letting us see how well huntingtin lowering...

1

22

34

LabScribbles Retweeted

The CONP believes many of the challenges faced by both fundamental and clinical neuroscientists can be tackled with #openscience approaches. Read about the multi-faceted approach the CONP is taking to enable open neuroscience in our recent preprint:

The Canadian Open Neuroscience Platform – An Open Science Framework for the Neuroscience Community

Large-scale data-centric challenges faced by neuroscientists, such as improving reproducibility and data reuse, could be overcome by adopting open science practises. The Canadian Open Neuroscience...

11

6

LabScribbles Retweeted

A genetically-tweaked Huntington's disease mouse model shows a tendency for the CAG repeat to grow, just like we see in humans with the mutation.

BAC to basics: a more accurate mouse model for Huntington's disease

A genetically-tweaked Huntington's disease mouse model shows a tendency for the CAG repeat to grow, just like we see in humans with the mutation.

15

33

LabScribbles Retweeted

Happy to learn one of our longest-ever efforts reached a milestone (not millstone) today with release of a chemical probe by ⁦

⁩ Big thanks on the synthesis from from Ivan ⁦

⁩ and a cast of many others. SGC-UBD253 | SGC

The probe and control may be requested here.

3

7

36

Show this thread

LabScribbles Retweeted

The first round of findings from the halted tominersen huntingtin lowering trial, GENERATION-HD1, run by Roche were shared this week with the HD community. HDBuzz explains what they found and what’s next.

Finding the silver lining: an update on the Roche GENERATION-HD1 trial data

The first round of findings from the halted tominersen huntingtin lowering trial, GENERATION-HD1, run by Roche were shared this week with the HD community. HDBuzz explains what they found and what’s...

4

30

44

LabScribbles Retweeted

Looks to be potentially exciting news from Roche and Ionis on the status of tominersen! We'll watch the community update on Thursday, and expect a Buzz story with details to follow.

Quote Tweet

Jeff Carroll, PhD

Very exciting update from @Roche and @ionispharma about their Huntingtin-lowering drug, tominersen. A new phase II study in earlier stage HD is apparently being planned... ir.ionispharma.com/news-releases/

Show this thread

4

19

63

LabScribbles Retweeted

UPCOMING HDSA RESEARCH WEBINAR JANUARY 20TH @ 3PM (ET) Please join us for an update from

with new key findings from the GENERATION-HD1 study. REGISTER TODAY: hdsa-org.zoom.us/webinar/regist #HuntingtonsDisease #HDSAFamily #LetsTalkAboutHD

1

14

24

LabScribbles Retweeted

In a much-needed bit of good news for the Huntington's disease community, Neurocrine Bioscience's KINECT-HD trial showed that treatment with valbenazine significantly reduced the involuntary movements called chorea

KINECT-HD trial shows valbenazine improves involuntary movements in Huntington's disease

In a much-needed bit of good news for the Huntington's disease community, Neurocrine Bioscience's KINECT-HD trial showed that treatment with valbenazine significantly reduced the involuntary moveme...

3

27

61

LabScribbles Retweeted

Communications Biology

@CherylArrowsmi1

describe the huntingtin (HTT) and HAP40 complex, demonstrating correlative abundance between the two and exploring conformational variety in the exon 1 region. nature.com/articles/s4200

8

10

All data for this project are openly available (links in the data availability statement) and you can find all of our tools for making the HTT samples on

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific intera...

Communications Biology - Harding et al. present a biophysical and structural characterization of the complex between huntingtin (HTT) and HAP40 proteins. They show that the abundance of HAP40 is...

1

5

Show this thread

Thanks to all of my wonderful coauthors and collaborators (those on twitter are tagged above) for their hard work and support. This was a real team effort and I am extremely grateful for all of your expertise and insight throughout this project.

1

3

Show this thread

Hoorah! Our HTT-HAP40 manuscript is now published. Read about how we used multiple structural approaches to investigate HTT structure to further defined the relationship of HTT/HAP40 and the structural consequences of polyQ expansion on HTT-HAP40. nature.com/articles/s4200

Susan Lea and 7 others

4

21

50

Show this thread

LabScribbles Retweeted

New tools let us “see” clumps of toxic huntingtin protein which build up in the brains of people with Huntington’s disease over time. Tracking these clumps might help us to better understand how HD progresses or how treatments might slow or halt HD.

“Seeing” the toxic huntingtin protein in people with HD

New tools let us “see” clumps of toxic huntingtin protein which build up in the brains of people with Huntington’s disease over time. Tracking these clumps might help us to better understand how HD...

1

27

42

LabScribbles Retweeted

UPCOMING HDSA RESEARCH WEBINAR Ask the Scientist ... ANYTHING! Join

on 12/7 at 12pm (ET) for a panel discussion on #HuntingtonsDisease research. Register today at hdsa-org.zoom.us/webinar/regist #LetsTalkAboutHD #HDSAFamily

9

9

LabScribbles Retweeted

NeuroLibre is a preprint server for interactive research objects. The team has been working with many partners and publishers to “go beyond the pdf”. Learn more about NeuroLibre and their collaborations #OpenData #OpenScience

NeuroLibre Collaborations

5

11

LabScribbles Retweeted

Tomorrow is the first day of

#OpenScienceInAction Symposium! Don't miss

and

discussing the partnership of

with

at 11.50am in the lunchtime breakout session #OpenScience #OpenData Register here: webapp.spotme.com/welcome/opensc

9

9

LabScribbles Retweeted

UPCOMING HDSA RESEARCH WEBINAR Ask the Scientist ... ANYTHING! Join

on 12/7 at 12pm (ET) for a panel discussion on #HuntingtonsDisease research. Register today at hdsa-org.zoom.us/webinar/regist #LetsTalkAboutHD #HDSAFamily

10

10

LabScribbles Retweeted

Jeff Carroll, PhD

We're hiring! We are launching a very cool allele-selective Huntingtin ASO study in mice, and are hiring a research scientist or postdoc to run it. Fully-funded, good salary ($65- $75K), great benefits, and Bellingham is awesome! hr.wwu.edu/careers-staff?

2

17

43

LabScribbles Retweeted

Matthieu Schapira

Mandeep Mann finds an exciting starting point for a USP5 chemical probe or #PROTAC. Great to work with Rima Al-Awar's med. chem. team at

and Rachel Harding

pubs.acs.org/doi/full/10.10

1

6

31

LabScribbles Retweeted

sciencedirect.com

AlphaFold and Implications for Intrinsically Disordered Proteins

Accurate predictions of the three-dimensional structures of proteins from their amino acid sequences have come of age. AlphaFold, a deep learning-base…

39

112

LabScribbles Retweeted

It’s so gratifying to see the success of the AI protein structure prediction programs, which is the culmination of years and years of work by so many. There’s John Moult of course, who spearheaded the CASP benchmarking initiative and built that community. 1/

2

22

72

Show this thread

LabScribbles Retweeted

LashuelNeuroLab

For your thoughtful weekend read! Rethinking #protein #aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity? #Alzheimers #Parkinsons #Huntingtons #als sciencedirect.com/science/articl

2

26

55

Show this thread

LabScribbles Retweeted

Be part of the structural revolution

@NCIResearchCtr

in Frederick- up to 6(!) postdoc positions with

in cryoEM of membrane proteins and nanomachines! Latest, cutting-edge EM hardware & awesome resources at all levels from the

! Contact: LeaLabRecruit@nih.gov

2

16

26