Boiler room but all of your friends are amino acids
Lada Nuzhna’s Tweets
allostery might happen but I am asserting that it is legal!
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putting together a rave machine for my proteins 🤖
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I never prioritized happiness in life (if anything, I think there are many things for which it's worth sacrificing happiness), and yet I feel like the happiest person of everyone I know. Every day is just such a gem, even when things are hard and do not work and everything fails
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math feels way more scientific in that sense. because it's easier to meet mathematicians proving fundamental theorems of arithmetic before using them than to meet a biologist redoing someone's gwas on their own cohort before relying on given stats.
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also - science is way closer to religion than you think. you can't start your research by replicating every assumption your project might rely on. so in a way, you just *believe* that other people were honest in their work.
unfortunately, it's often #science and not science
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the hill I will die on - evolution, not laws of physics, is the first-principles way to think about biology
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Replying to @noampomsky
Easy to imagine you’re thinking from first principles when you don’t understand the tradition/development of a particular field
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True but also here is a cute example of people reducing the complexity of protein space search from O(N^2) / O(N^3) to O(NlogN) using N-body physics methods. biorxiv.org/content/10.110
So many ideas can be born because you randomly read papers across the fields!
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The physics-major-turned-ML-researcher who nervously reassures themselves that physics was a great foundation for ML but deep down knows that all those all-nighters spent solving Lagrangians doesn’t have shit to do with their full-time job of hyperparameter tuning
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the last 48 hours have been non-stop decorating, robots and 3d printing setup, AI Louvre, and learning 1-arm pushups with
extra excited to be back in Bay for a little bit to host an epic year finale for loved ones ❤️
partiful.com/e/qK6ecBLIW1po
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Here's a cool summary of our recent @NatureAging with some quotes from me! scienmag.com/solar-powered-
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they are very much single-handedly creating a new area of aging research.
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this work has been one of the big wins of & it is now out at Nature Aging (in just 1 year!)
some context - even our reviewer team commented that the proposal was too risky, but funded nevertheless. how many of such ideas wouldn't pass traditional review?
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I am happy to share that our manuscript has finally seen the Light (!!) of day in @NatureAging :)
@impetusgrants
The concept of external Energy Replacement to treat aging is still new and I am eager to see what the future brings!
#aging #mitochiondria
nature.com/articles/s4358
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using them almost every day btw! recently asked it how to best fuse 2 proteins I am working with and it gave me essentially the same response i got from reading structural protein papers for 2+ weeks
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Replying to @LauraDeming
Write about how you use them! I haven't gotten much value from them yet.
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so we can either lower bar for what it takes to be a biotech founder or raise the bar for what we consider to be biotech
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you are right in that any joe from streets can be a biotech founder. but who cares? we have legions of those & i have no idea what good do they do apart from talking on podcasts and being on forbes 30 under 30.
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the flawed assumption that the goal should be to start a biotech company or to be a biotech founder...
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lol
there is no royal road to good biotech companies without deep knowledge of biology
sorry, next
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Replying to @SofiasBio
flawed assumption that being a biotech founder requires deep knowledge of biology
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feels like only yesterday you were taking work calls on our way to burning man, scrambling to get all the parts for this boat
the build speed of this was insane
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today my dear friend launches her absolutely mindblowing sexy electric flying boat at Art Basel! she dedicated her PhD to Tony Stark but is now becoming so much cooler than him
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We're Navier, the #boat of the future.
Go 75nmi at 20kt with our #electric engine. Sail peacefully with #hydrofoil tech that allows the boat to fly above 4 ft waves. And relax while #autonomous tech enables a hands-free driving experience.
More here: navierboat.com
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So much respect for Richard Miller & his work on ITP, especially given that their ground truth has no regard for what is currently popular. It either extends lifespan or not.
Many critical clues about senescence that would be great to explore in the next round of
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A new Richard Miller / ITP / Longevity Drug interview: youtube.com/watch?v=hHlDTi
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I had a dream that Elon bought Benchling to fully rebuild it, with George Hotz implementing a multi-user editing feature.
I didn’t want to wake up.
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How to scale enzyme production - hire 100 MIT undergrads to do the same procedure in 1.5 ml tubes 100 times. Lessons from Okazaki 🌚
from "For the Love of Enzymes: The Odyssey of a Biochemist by Arthur Kornberg"
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Sometimes you walk into a place and can feel the positive energy. is one of these places! Great to visit the institute, hear about the research happening there, and catch up with the inspiring & .
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It's easier to have a bold vision when you aren't working on the hardest part of the problem. Which is why I have infinite admiration for people doing science & daring to aspire for the quirky word ‘immortal’.
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Somewhat sad that people who converge on lifespan extension and immortality as a vision (as opposed to 'healthy aging') are primarily outside of the science realm -> can't take direct responsibility for making things happen IN the science of aging itself
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Join us during the Founder-Led Biotech Summit next week as we explore the recent explosion of new models for biotech innovation with , & .
Register here: hopin.com/events/founder
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Also, it is an end of an era for me - probably my last painting ever. I went through 6 years of art school at some point (although my medium was watercolor, not oil or acrylic) and I don’t think I would have done it if I knew we will get Dalle. Alas!
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I was thinking about what Dalle can not do - and realized it can’t probably parametrize things meaningfully. So I encoded 10 golden ratios throughout my painting (thats how you know I am human - basically a hyper obnoxious captcha ).
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Here is your NIH white pill. Things outside of this are still pretty slow, but I think we should give credit where it's due.
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I just chatted with PIs from Gladstone&Berkeley who mentioned they received response & money fast but also had to meet with RADx EVERY day to update them about the progress they were making. Also, the program started just around the same time as Fast Grants.
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Something I haven't seen anyone talk about - NIH actually DID have fast grants during COVID (not the one where they repurpose existing funding - an actual separate program!), RADx. And it funded a number of important projects during the pandemic!
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One of the most important projects we funded in the previous round is hiring:
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Please RT, our lab @InflamAge_UoB is hiring!
We are looking for a researcher/developer to work on our online resources for ageing science, in particular develop a compilation of open problems in longevity science @impetusgrants
Deadline Oct 26, 2022.
edzz.fa.em3.oraclecloud.com/hcmUI/Candidat
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@impetusgrants-funded paper is out at @NatureBiotech - circuits targeting signatures of transcriptome
@SynBioGaoLab huge congrats
nature.com/articles/s4158
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If you really care to learn from history - look at the last 20 years of RF. Each time they would get the piece of land they wanted through violence & silent agreement from the rest of us.
en.wikipedia.org/wiki/Russo-Geo
en.wikipedia.org/wiki/Second_Ch
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If I don't read it, is there any chance I can forget about this?
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And when we all thought that epigenetics can't get worse than this, a new paper dropped, describing the regulation of RNAs by transcription factors
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Excited to share our work on "top-down" reinforcement learning based approach to design proteins with exquisite structural control. The Monte Carlo tree search algorithm generate protein monomers and assemblies, guided by input geometric constraints. 1/4 biorxiv.org/content/10.110
read image description
ALT
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Whom should I meet / know in London?
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I was genuinely always confused when someone would tell me that school slows down your learning. Now it just seems so obvious. Home-schooled kids who cover college material by age of 12 are not genius - they are the norm.
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Counted just now: covered more textbooks since I dropped out (less than a year) than during 3 years of college. Retaining capacity also became much higher cus stuff is immediately relevant to what I do. There is no speed limit ❣️
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One of the most life-changing periods for me where when my close friend, Vincent Li, showed me that it was possible to learn 2 years worth of material in statistics in a 3 months summer break by self-teaching with intense focus.
He inspired this group:
facebook.com/groups/inspire
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